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5.00511

Histone Acetyltransferase Inhibitor VIII, NU9056

Synonym(s):

Histone Acetyltransferase Inhibitor VIII, NU9056, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V, 1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I

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Size/SKUAvailabilityPrice
10 mg
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€ 243,00

About This Item

Empirical Formula (Hill Notation):
C6H4N2S4
CAS Number:
1450644-28-6
Molecular Weight:
232.37
MDL number:
MFCD26792588
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
oil
Storage condition:
OK to freeze, protect from light

€ 243,00

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assay

≥97% (HPLC)

Quality Segment

100

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow-brown

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

SMILES string

[s]1nccc1SSc2[s]ncc2

InChI

1S/C6H4N2S4/c1-3-7-9-5(1)11-12-6-2-4-8-10-6/h1-4H

InChI key

MLRAMCAHIWHWRM-UHFFFAOYSA-N

General description

NU9056, a disulfane compound, is reported to be a potent inhibitor of lysine acetyltransferase 5 (KAT5). NU9056 inhibits protein acetylation in prostate cancer cell lines. It acts against histone acetyltransferase KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100 µM, respectively) and effectively reduces H3K14, H4K8, H4K16, but not α-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10 µM). Shown to induce cell cycle arrest and apoptosis (17 to 24 µM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27 µM).[1]

Biochem/physiol Actions

Cell permeable: yes
Primary Target
KAT5
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
382175-M5.09703218860
Histone Acetyltransferase Inhibitor VIII, NU9056

Sigma-Aldrich

5.00511

Histone Acetyltransferase Inhibitor VIII, NU9056

Histone Deacetylase Inhibitor VIII The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Millipore

382175-M

Histone Deacetylase Inhibitor VIII

LSD1 Inhibitor VII, SP-2509

Sigma-Aldrich

5.09703

LSD1 Inhibitor VII, SP-2509

Casein Kinase II Inhibitor VIII The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

218860

Casein Kinase II Inhibitor VIII

form

oil

form

solid

form

solid

form

solid

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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