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5.00511

Histone Acetyltransferase Inhibitor VIII, NU9056

Synonym(s):

Histone Acetyltransferase Inhibitor VIII, NU9056, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V, 1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I

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Size/SKUAvailabilityPrice
10 mg
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$277.00

About This Item

Empirical Formula (Hill Notation):
C6H4N2S4
CAS Number:
1450644-28-6
Molecular Weight:
232.37
MDL number:
MFCD26792588
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
oil
Storage condition:
OK to freeze, protect from light

$277.00

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assay

≥97% (HPLC)

Quality Segment

100

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow-brown

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

SMILES string

[s]1nccc1SSc2[s]ncc2

InChI

1S/C6H4N2S4/c1-3-7-9-5(1)11-12-6-2-4-8-10-6/h1-4H

InChI key

MLRAMCAHIWHWRM-UHFFFAOYSA-N

General description

NU9056, a disulfane compound, is reported to be a potent inhibitor of lysine acetyltransferase 5 (KAT5). NU9056 inhibits protein acetylation in prostate cancer cell lines. It acts against histone acetyltransferase KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100 µM, respectively) and effectively reduces H3K14, H4K8, H4K16, but not α-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10 µM). Shown to induce cell cycle arrest and apoptosis (17 to 24 µM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
KAT5
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
382175M509703382113
Histone Acetyltransferase Inhibitor VIII, NU9056

Sigma-Aldrich

500511

Histone Acetyltransferase Inhibitor VIII, NU9056

Histone Deacetylase Inhibitor VIII The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Millipore

382175M

Histone Deacetylase Inhibitor VIII

LSD1 Inhibitor VII, SP-2509

Sigma-Aldrich

509703

LSD1 Inhibitor VII, SP-2509

Histone Acetyltransferase p300 Inhibitor, C646 Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket.

Sigma-Aldrich

382113

Histone Acetyltransferase p300 Inhibitor, C646

description

-

description

The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

description

-

description

Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket.

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (sum of isomers, HPLC)

form

oil

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 50 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 50 mg/mL

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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