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5.04841

5,7-Dichlorokynurenic Acid, Sodium Salt

Synonym(s):

5,7-Dichlorokynurenic Acid, Sodium Salt, 5,7-Dichloro-4-hydroxyquinoline-2-c-arboxylic acid sodium salt, DCKA

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10 mg
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$86.00

About This Item

Empirical Formula (Hill Notation):
C10H4Cl2NNaO3
CAS Number:
1184986-70-6
Molecular Weight:
280.04
MDL number:
MFCD00674925
UNSPSC Code:
12352106
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light

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assay

≥99% (HPLC)

Quality Segment

100

form

solid

potency

79 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 10 mM, 1 M NaOH: 100 mM

storage temp.

2-8°C

SMILES string

[Na+].Clc1c2c(nc(cc2O)C(=O)[O-])cc(c1)Cl

InChI

1S/C10H5Cl2NO3.Na/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14;/h1-3H,(H,13,14)(H,15,16);/q;+1/p-1

InChI key

VPRPMJHKWHCUFW-UHFFFAOYSA-M

General description

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (Ki = 79 nM vs. [3H]-glycine).

Biochem/physiol Actions

Primary Target
NMDA receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Baron, B., et al. 1991. Eur. J. Pharmacol.206, 149.
Baron, B., et al. 1990. Mol. Pharmacol.38, 554.
Mugnaini, M., et al. 1998. J. Recept. Signal Transduct. Res.18, 91.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
504844475874M102498
5,7-Dichlorokynurenic Acid, Sodium Salt

Sigma-Aldrich

504841

5,7-Dichlorokynurenic Acid, Sodium Salt

7-Chlorokynurenic Acid Sodium Salt

Sigma-Aldrich

504844

7-Chlorokynurenic Acid Sodium Salt

MK571, Sodium Salt A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

Millipore

475874M

MK571, Sodium Salt

Chromotropic acid disodium salt dihydrate for analysis ACS,Reag. Ph Eur

Supelco

102498

Chromotropic acid disodium salt dihydrate

description

-

description

-

description

A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

description

for analysis ACS,Reag. Ph Eur

assay

≥99% (HPLC)

assay

≥99% (HPLC)

assay

≥90% (HPLC)

assay

≥98.5% (acidimetric)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-30°C

solubility

water: 10 mM, 1 M NaOH: 100 mM

solubility

water: 100 mM

solubility

DMSO: 10 mg/mL, water: 200 mg/mL

solubility

-

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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