516481-M
Pepstatin A, Synthetic
Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.
Synonym(s):
Pepstatin A, Synthetic, Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $75.50 |
25 mg | Check Cart for Availability | $228.00 |
100 mg | Check Cart for Availability | $643.00 |
About This Item
$75.50
description
Merck USA index - 14, 7147
Quality Segment
assay
≥98% (HPLC)
form
solid
optical activity
[α]20.0/D -90.0±5.0, c = 0.5 in methanol
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 1 mg/mL, methanol: 1 mg/mL
storage temp.
2-8°C
SMILES string
N([C@@H](C(C)C)C(=O)NC(C(O)CC(=O)N[C@@H](C)C(=O)NC(C(O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)CC(C)C)C(C)C
InChI
1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1
InChI key
FAXGPCHRFPCXOO-JHTFMCFMSA-N
General description
Biochem/physiol Actions
cathepsin D
Preparation Note
Other Notes
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.
Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.
Legal Information
Disclaimer
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This Item | |||
|---|---|---|---|
| description Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. | description An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7). | description from Streptomyces species | description A Pepstatin A that is ~75% less potent against Cathespins D/E than PepA in cell-free assays. |
| assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay - | assay ≥97% (HPLC) |
| form solid | form solid | form lyophilized | form lyophilized solid |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Roche | manufacturer/tradename Calbiochem® |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 1 mg/mL, methanol: 1 mg/mL | solubility 50% acetic acid: 5 mg/mL | solubility ethanol: 1 mg/mL, methanol: 1 mg/mL, acetic acid: soluble 300 μg/mL (6N), pyridine: soluble, water: insoluble | solubility water: 1 mg/mL |
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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