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5.30153

JAK2 Inhibitor X, FLLL32

Synonym(s):

JAK2 Inhibitor X, FLLL32, STAT3 Signaling Inhibitor, FLLL32

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Size/SKUAvailabilityPrice
25 mg
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$247.00

About This Item

Empirical Formula (Hill Notation):
C28H32O6
CAS Number:
1260115-54-5
Molecular Weight:
464.55
MDL number:
MFCD12922514
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light

$247.00

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assay

≥98% (HPLC)

Quality Segment

100

form

powder

potency

5 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

General description

A cell permeable diketone analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 µM) and blocks STAT3 phosphorylation in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. However, it does not affect STAT3 phosphorylation in normal human mammary epithelial cells or human pancreatic duct epithelial cells. Does not block the activity of tyrosine kinases containing SH2 and SH2-SH3 domains and several other kinases, such as Akt2, Cdk2-cyclin D1, EGFR kinase, Met, and EbrB2/Her2 kinase (IC50 >100 µM). Also shown to block DNA binding activity of STAT3. Significantly reduces the viability and invasion capacity of various cancer cells (IC50 = 640 nM; 110 nM, 140 nM, 600 nM, 400 nM in PANC-1, HPAC, MDA-MB-231, SK-BR3, and SUM-159 cells, respectively) and induces apoptosis. Shown to significantly reduce tumor burdens in the MDA-MB-231 xenografted mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
JAK2
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wu, J., et al. 2014. Oncogene33,173.
Onimoe, G., et al. 2012. Invest. New Drugs30, 916.
Li, L., et al. 2010. Cancer Res.70, 2445.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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JAK2 Inhibitor X, FLLL32

Sigma-Aldrich

530153

JAK2 Inhibitor X, FLLL32

STAT3 Inhibitor XVIII, BP-1-102 The STAT3 Inhibitor XVIII, BP-1-102 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Millipore

573132M

STAT3 Inhibitor XVIII, BP-1-102

p300/CBP Inhibitor X, EML425

Sigma-Aldrich

534354

p300/CBP Inhibitor X, EML425

Wnt-β-Catenin Signaling Inhibitor, FzM1

Sigma-Aldrich

534358

Wnt-β-Catenin Signaling Inhibitor, FzM1

description

-

description

The STAT3 Inhibitor XVIII, BP-1-102 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

-

description

-

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 100 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 100 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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