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5.30729

AAA-ATPase Drg1 Inhibitor, Diazaborine

Synonym(s):

AAA-ATPase Drg1 Inhibitor, Diazaborine, 2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor

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Size/SKUAvailabilityPrice
10 mg
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$271.00

About This Item

Empirical Formula (Hill Notation):
C14H13BN2O3S
CAS Number:
22959-81-5
Molecular Weight:
300.14
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light

$271.00

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assay

≥98% (HPLC)

Quality Segment

100

form

powder

potency

26 μM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

General description

A diazaborine derivative with anti-bacterial properties against a wide range of Gram-negative bacteria. Shown to target NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR), which results in the inhibition of bacterial fatty acid synthase. Blocks the maturation of ribosomal RNA for the large 60S ribosomal subunit in yeast cells by binding to the D2 domain of AAA-ATPase Drg1 (Ki = 26 µM) resulting in reduced ATP hydrolysis and release of Rip24 from pre-60S particles.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Drg1 AAA-ATPase
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Loibl, M., et al. 2014. J. Biol. Chem. 289, 3913.
Pertschy B., et al. 2004. Mol. Cell. Biol. 24, 6476.
Baldock, C. et al. 1998. Biochem. Pharmacol. 55, 1541.
Grassberger M., et al. 1984. J Med Chem.27, 947.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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217708565851672999
AAA-ATPase Drg1 Inhibitor, Diazaborine

Sigma-Aldrich

530729

AAA-ATPase Drg1 Inhibitor, Diazaborine

Cdc42/Rac1 GTPase Inhibitor, ML141 The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

217708

Cdc42/Rac1 GTPase Inhibitor, ML141

SHP1/2 PTPase Inhibitor, NSC-87877 The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

565851

SHP1/2 PTPase Inhibitor, NSC-87877

V-ATPase Inhibitor, KM91104

Sigma-Aldrich

672999

V-ATPase Inhibitor, KM91104

description

-

description

The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Membrane applications.

description

The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

-

assay

≥98% (HPLC)

assay

≥99% (HPLC)

assay

≥97% (HPLC)

assay

>98% (HPLC)

form

powder

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 100 mg/mL

solubility

DMSO: 50 mg/mL

solubility

water: 10 mg/mL

solubility

DMSO: 100 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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