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5.30746

Peroxiredoxin Inhibitor, Conoidin A

Synonym(s):

Peroxiredoxin Inhibitor, Conoidin A, 2,3- bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor, 2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor

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Size/SKUAvailabilityPrice
25 mg
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$291.00

About This Item

Empirical Formula (Hill Notation):
C10H8Br2N2O2
CAS Number:
Molecular Weight:
347.99
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (NMR)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light

$291.00


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assay

≥95% (NMR)

Quality Segment

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

yellow-brown

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

SMILES string

BrCC1=C(N(c2c(cccc2)[N+]1=O)[O-])CBr

InChI

1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2

InChI key

DQKNFTLRMZOAMG-UHFFFAOYSA-N

General description

A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Peroxiredoxin
Reversible: no
Target IC50: 23 µM for blocking TgPrxII hyperperoxidation activity

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Use only fresh DMSO for reconstitution.

Other Notes

Nguyen, J.B., et al. 2013. Chem. Biol.20, 991.
Haraldsen, J. D., et al. 2009. Org. Biomol. Chem.7, 3040.
Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA101, 7433.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

form

solid

form

powder

form

solid

form

solid

assay

≥95% (NMR)

assay

≥94% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 50 mg/mL

solubility

ethanol: 10 mg/mL, DMSO: 25 mg/mL


hcodes

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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