Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

5.33162

RAN Translation Inhibitor, NSC311153

Synonym(s):

RAN Translation Inhibitor, NSC311153, 9-Hydroxy-5,11-dimethyl-2-(2-(piperidin-1-yl)ethyl)-6H-pyrido[4,3-b]carbazol-2-ium Bromide, HBr, 9-Hydroxy-5,11-dimethyl-2-(2-(piperidyl)ethyl)-6H-pyrido(4,3-b)carbazolium Bromide, HBr, (GGGGCC)exp RNA Inhibitor, NSC-311153, NSC 311153

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
10 mg
Check Cart for Availability
$228.00

About This Item

Empirical Formula (Hill Notation):
C24H28BrN3O · xHBr
Molecular Weight:
454.40 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥96% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

$228.00

Check Cart for Availability
​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥96% (HPLC)

Quality Segment

100

form

solid

potency

9.7 μM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

orange

solubility

water: 5 mg/mL, DMSO: 50 mg/mL

storage temp.

2-8°C

General description

A cell permeable indole fused isoquinolinium salt that binds to the expanded repeat (r(GGGGCC)exp (Kd = 9.7 µM) with modest selectivity. This binding is dependent upon the ionic strength and appears to be significantly weaker in the presence of Na+ and K+. Inhibits repeat-associated non-ATG (RAN) translation and foci Formation in r(GGGGCC)66-expressing HEK293 cells and reduces the levels of poly(GP) and poly(GA) proteins (10% at 25 µM; 47% at to 100 µM). Also shown to inhibit RAN translation and foci formation in (GGGGCC)exp-expressing C9ORF72+ iNeurons (~ 2 µM).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
(r(GGGGCC)exp
Reversible: yes

Packaging

Packaged under inert gas

Physical form

Supplied as HBr salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Su, Z., et al. 2014. Neuron.83, 1043.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
509265557404M557403
RAN Translation Inhibitor, NSC311153

Sigma-Aldrich

533162

RAN Translation Inhibitor, NSC311153

RNA Polymerase I Inhibitor II, CX-5461

Sigma-Aldrich

509265

RNA Polymerase I Inhibitor II, CX-5461

RNA Polymerase III Inhibitor InSolution, ≥97%

Millipore

557404M

RNA Polymerase III Inhibitor

RNA Polymerase III Inhibitor RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC50= 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

Sigma-Aldrich

557403

RNA Polymerase III Inhibitor

description

-

description

-

description

InSolution, ≥97%

description

RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC50= 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

assay

≥96% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

form

solid

form

powder

form

liquid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters