The stability of stock solutions stored at 4 °C has not been investigated. To avoid repeated freeze/thaw cycles, which may cause degradation, aliquots may be prepared in single use volumes for storage at −20°C.
5.34339
PTPσ Inhibitor, ISP
Synonym(s):
PTPσ Inhibitor, ISP, Protein Tyrosine Phosphatase σ Inhibitor, ISP
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $307.00 |
About This Item
Empirical Formula (Hill Notation):
C177H306N66O54S3
Molecular Weight:
4318.93
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
$307.00
Check Cart for Availability
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
DMSO: 100 mg/mL, water: 100 mg/mL
storage temp.
−20°C
General description
A cell-permeable, TAT conjugated peptide derived from the protein tyrosine phosphatase sigma (PTPsigma) wedge domain that binds to PTPsigma and relieves glial-derived chondroitin sulfate proteoglycan (CSPG)-mediated inhibition. Shown to cross the blood-brain barrier. Does not bind to other CSPG receptors, such as LAR and NgRs. By blocking the PTPsigma-CSPG interaction it abolishes CSPG -mediated inhibition of axonal regrowth and sprouting. Shown to promote adult sensory neuron growth cone (~ 2.5 µM). Restores serotonergic innervations to the spinal cord below the level of injury and promotes progressive functional recovery of both locomotor and urinary systems after spinal cord injury in a rat model (11 µg/day).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PTPσ
PTPσ
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lang, B. T, et al. 2015. Nature.518, 404.
NH2-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
1 of 1
This Item | |||
|---|---|---|---|
| description - | description The PTP Inhibitor IV, also referenced under CAS 329317-98-8, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. | description The PTP CD45 Inhibitor, also referenced under CAS 345630-40-2, controls the biological activity of PTP CD45. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. | description The TNAP Inhibitor, also referenced under CAS 496014-13-2, controls the biological activity of TNAP. This small molecule/inhibitor is primarily used for Cell Structure applications. |
| form solid | form solid | form solid | form solid |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 100 mg/mL, water: 100 mg/mL | solubility DMSO: 10 mg/mL, acetonitrile: soluble | solubility DMSO: 5 mg/mL, ethanol: 5 mg/mL | solubility DMSO: 50 mg/mL |
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Is it okay to store aliquots at 4C for several weeks rather than go through multiple freeze-thaw cycles?
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