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5.38256

IDO Inhibitor

Synonym(s):

IDO Inhibitor, 4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor

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Size/SKUAvailabilityPrice
10 mg
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$209.00

About This Item

Empirical Formula (Hill Notation):
C9H7ClFN5O2
CAS Number:
914471-09-3
Molecular Weight:
271.64
MDL number:
MFCD28142835
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light

$209.00

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assay

≥98% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

SMILES string

Fc1c(cc(cc1)\N=C(\NO)/c2n[o]nc2N)Cl

InChI key

HGXSLPIXNPASGZ-UHFFFAOYSA-N

General description

A cell-permeable, bioactive, non-toxic oxadiazolohydroxyamidine based compound that acts as a potent, selective and competitive inhibitor of indoleamine 2,3-dioxygenase (IDO; IC50 = 67 nM for hIDO). Reversibly binds to the catalytically active heme iron (Fe2+) and is inactive towards closely related tryptophan 2,3-dioxygenase (TDO; IC50 >10 µM). Shown to dose-dependently decrease kynurenine levels (IC50 = 19 & 46 nM in HeLa treated with IFN-γ & B16-GM-CSF melanoma cells, respectively) and suppress B16-GM-CSF xenograft tumor growth in C57BL/6 mice (75 mg/kg, s.c., b.i.d.). Though orally bioavailable, but undergoes a rapid clearance (t1/2<0.5 h).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: no
Primary Target
IDO
Reversible: yes
Target IC50: 67 nM for hIDO

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yue, E.W., et al. 2009. J. Med. Chem.52, 7364.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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IDO Inhibitor

Sigma-Aldrich

538256

IDO Inhibitor

Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1 clone 10.1, Upstate&#174;, from mouse

Sigma-Aldrich

05840

Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1

CDC25 Phosphatase Inhibitor I, BN82002 The CDC25 Phosphatase Inhibitor I, BN82002, also referenced under CAS 396073-89-5, controls the biological activity of CDC25 Phosphatase. This small molecule/inhibitor is primarily used for Phosphorylation &amp; Dephosphorylation applications.

Sigma-Aldrich

217691

CDC25 Phosphatase Inhibitor I, BN82002

MEK1/2 Inhibitor III The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation &amp; Dephosphorylation applications.

Sigma-Aldrich

444966

MEK1/2 Inhibitor III

description

-

description

clone 10.1, Upstate®, from mouse

description

The CDC25 Phosphatase Inhibitor I, BN82002, also referenced under CAS 396073-89-5, controls the biological activity of CDC25 Phosphatase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥98% (HPLC)

assay

-

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

powder

form

-

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Upstate®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL

solubility

-

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL

solubility

DMSO: 20 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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