662005
U0126
≥98% (HPLC), solid, MEK inhibitor, Calbiochem®
Synonym(s):
U0126, 1,4-Diamino-2,3-dicyano-1,4- bis(2-aminophenylthio)butadiene, MEK Inhibitor VI, 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene, MEK Inhibitor VI
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Check Cart for Availability | $109.00 |
5 mg | Check Cart for Availability | $351.00 |
10 mg | Check Cart for Availability | $523.00 |
20 mg | Check Cart for Availability | $857.00 |
About This Item
$109.00
Product Name
U0126, U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
S(c2c(cccc2)N)\C(=C(\C(=C(\Sc1c(cccc1)N)/N)\C#N)/C#N)\N
InChI
1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChI key
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
General description
Biochem/physiol Actions
MEK1 and MEK2
Packaging
Preparation Note
Other Notes
DeSilva, D.R., et al. 1998. J. Immunol. 160, 4175.
Duncia, J.V., et al. 1998. Biorg. Med. Chem. Lett.8, 2839.
Favata, M.F., et al. 1998. J. Biol. Chem. 273, 18623.
Legal Information
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| description U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. | description InSolution, ≥98%, A potent and specific inhibitor of MEK1 and MEK2 | description A useful negative control for MEK inhibitors U0125 and U0126. | description ≥98% (HPLC), powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| form solid | form liquid | form solid | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - |
| storage temp. −20°C | storage temp. −70°C | storage temp. −20°C | storage temp. 2-8°C |
| storage condition OK to freeze, protect from light | storage condition OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light | storage condition OK to freeze, protect from light | storage condition protect from light |
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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