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8.09692

o-Cresol

for synthesis

Synonym(s):

o-Cresol, 2-Hydroxytoluene, 2-Methylphenol

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100 ML

$52.30

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$61.00

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$63.60

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$114.00

$52.30

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About This Item

Linear Formula:
2-(CH3)C6H4OH
CAS Number:
95-48-7
Molecular Weight:
108.14
UNSPSC Code:
12352104
EC Index Number:
202-423-8
NACRES:
NA.22
MDL number:
MFCD00002226
Assay:
≥99% (GC)
Grade:
synthesis grade
Bp:
191-192 °C/1013 hPa
Vapor pressure:
0.24 hPa ( 20 °C)

Key Documents

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grade

synthesis grade

Quality Level

200

vapor pressure

0.24 hPa ( 20 °C)

assay

≥99% (GC)

form

solid

autoignition temp.

555 °C

potency

121 mg/kg LD50, oral (Rat), 890 mg/kg LD50, skin (Rabbit)

expl. lim.

1.3 % (v/v)

dilution

(for synthesis)

pH

4.8 (20 °C, 20 g/L in H2O)

bp

191-192 °C/1013 hPa

mp

31 °C

transition temp

flash point 81 °C

solubility

20 g/L

density

1.046 g/cm3 at 20 °C

storage temp.

no temp limit

SMILES string

Oc1c(cccc1)C

InChI

1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3

InChI key

QWVGKYWNOKOFNN-UHFFFAOYSA-N

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1 of 4

This Item
8.052238.02295C85700
o-Cresol for synthesis

Sigma-Aldrich

8.09692

o-Cresol

p-Cresol for synthesis

Sigma-Aldrich

8.05223

p-Cresol

4-Chloro-3-methylphenol for synthesis

Sigma-Aldrich

8.02295

4-Chloro-3-methylphenol

o-Cresol ReagentPlus®, ≥99%

Sigma-Aldrich

C85700

o-Cresol

assay

≥99% (GC)

assay

≥98.0% (GC)

assay

≥99.0% (GC)

assay

≥99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

20 g/L

solubility

-

solubility

3.9 g/L

solubility

-

form

solid

form

solid

form

powder

form

solid or liquid

expl. lim.

1.3 % (v/v)

expl. lim.

1 % (v/v)

expl. lim.

-

expl. lim.

1.47 %, 148 °F

pH

4.8 (20 °C, 20 g/L in H2O)

pH

-

pH

6.5 (20 °C, 1 g/L in H2O)

pH

4.5 (25 g/L)

Application

o-Cresol can be used as a starting material to synthesize:
  • Carvacrol by alkylation reaction with propylene or isopropyl alcohol in the presence of Zr/mesoporous silica as a catalyst.
  • Polyisobutylenes by selective cationic polymerization of isobutylene using AlCl3 as a catalyst.
  • Poly(o-cresol) via oxidative coupling polymerization reaction in the presence of substituted pyridine/CuCl catalysts.

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Melting range (lower value): ≥ 29 °C
Melting range (upper value): ≤ 33 °C
Water (K. F.): ≤ 0.10 %
Identity (IR): passes test
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

flash_point_f

177.8 °F - closed cup

flash_point_c

81.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis of highly reactive polyisobutylene by selective polymerization with o-cresol/AlCl3 initiating system
Zhang LB, et al.
Polymers For Advanced Technologies, 23(3) (2012)
Synthesis of poly (o-cresol) by oxidative coupling polymerization of o-cresol
Aiba M, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 57(8) (2019)
Synthesis of carvacrol by Friedel-Crafts alkylation of o-cresol with isopropanol using superacidic catalyst UDCaT-5
Yadav GD and Kamble SB
Journal of Chemical Technology and Biotechnology, 84(10) (2009)
Synthesis of carvacrol by Friedel-Crafts alkylation of o-cresol with isopropanol using superacidic catalyst UDCaT-5
Yadav GD and Kamble SB
Journal of Chemical Technology and Biotechnology, 84(10) (2009)

Global Trade Item Number

SKUGTIN
809692100004022536402222
809692999904022536402246
809692250004022536402239
809692010004022536402208
809692050004022536402215

Questions

  1. Hello, Is it possible to get o-cresol in liqudi form?

    1 answer

    1. While the physical form of this product is not a specification, the material may present as a liquid or a solid. The melting point of this compound is approximately 31°C, gentle warming will re-liquify the product without harming the quality.
      There are other o-Cresol product options available that report the physical form on a lot-specific basis. This information is available in the product Certificate of Analysis. Please see the following links to review these products:
      https://www.sigmaaldrich.com/product/sigald/c85700
      https://www.sigmaaldrich.com/product/aldrich/w348007

      Please see the links below to review a sample or lot-specific Certificate for each item listed above. It is recommended to preview a Certificate of Analysis for current lots in stock, before purchasing either product:
      https://www.sigmaaldrich.com/product/sigald/c85700#product-documentation
      https://www.sigmaaldrich.com/product/aldrich/w348007#product-documentation

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