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8.52011

Fmoc-Leu-OH

Novabiochem®

Synonym(s):

Fmoc-Leu-OH, N-α-Fmoc-L-leucine

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25 g
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$46.90
100 g
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$115.00
250 g
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$248.00
500 g
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$455.00
1 kg
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$816.00
2 kg
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$1,540.00
5 kg
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$3,310.00

About This Item

Empirical Formula (Hill Notation):
C21H23NO4
CAS Number:
Molecular Weight:
353.41
UNSPSC Code:
12352209
EC Index Number:
252-662-7
NACRES:
NA.22
MDL number:

$46.90


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Quality Level

product line

Novabiochem®

assay

≥98% (TLC), ≥98.0% (acidimetric), ≥99.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

145-153 °C

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-30°C

SMILES string

N(C(CC(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)

InChI key

CBPJQFCAFFNICX-UHFFFAOYSA-N

General description

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of leucine amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS

Application

  • Fmoc-protection efficiency: Addressing the efficiency and recrystallization needs in the Fmoc-protection process (R Yoshino et al., 2017).
  • Isotopic labeling for NMR: Development of 17O isotopic labeling of N-Formyl-MLF-OH and related building blocks, enhancing NMR spectroscopy applications (M Ha et al., 2021).
  • Perovskite solar cell modification: Investigating the role of Fmoc-Leu-OH in modifying perovskite film to enhance solar cell efficiency (J Song et al., 2022).

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.8 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Leu-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Leu-Leu-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Ile-OH (GC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1025

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
8.521458.521398.52014
form

powder

form

powder

form

powder

form

powder

assay

≥98% (TLC), ≥99.0% (HPLC), ≥98.0% (acidimetric)

assay

≥95.0% (acidimetric), ≥98% (TLC), ≥99.0% (HPLC)

assay

≥95.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

assay

≥96.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

functional group

Fmoc

functional group

Fmoc

functional group

Fmoc

functional group

Fmoc

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

mp

145-153 °C

mp

-

mp

113-116 °C

mp

135-145 °C


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Storage Class

11 - Combustible Solids

wgk

WGK 3



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Global Trade Item Number

SKUGTIN
852011050004027269179564
852011500004027269221546
852011002504027269085056
852011901504027269242497
852011010004027269085063
852011901004027269221362
852011025004027269206963
852011200004027269232740
852011902504027269242480
852011100004027269179571

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