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8.52092

Fmoc-Dab(Mtt)-OH

Novabiochem®

Synonym(s):

Fmoc-Dab(Mtt)-OH, N-α-Fmoc-N-γ-4-methyltrityl-L-diaminobutanoic acid

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About This Item

Empirical Formula (Hill Notation):
C39H36N2O4
CAS Number:
Molecular Weight:
596.71
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22
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Quality Segment

product line

Novabiochem®

assay

≥95% (TLC), ≥95.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

15-25°C

SMILES string

N([C@@H](CCNC(c6ccc(cc6)C)(c5ccccc5)c4ccccc4)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C39H36N2O4/c1-27-20-22-30(23-21-27)39(28-12-4-2-5-13-28,29-14-6-3-7-15-29)40-25-24-36(37(42)43)41-38(44)45-26-35-33-18-10-8-16-31(33)32-17-9-11-19-34(32)35/h2-23,35-36,40H,24-26H2,1H3,(H,41,44)(H,42,43)/t36-/m0/s1

InChI key

RXKBBKLPMHPIKD-BHVANESWSA-N

General description

The side-chain Mtt group can be selectively removed with 1% TFA in DCM [1,2,3] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) [4], making this an excellent derivative for the synthesis by Fmoc SPPS of branched peptides and peptides modified at the Dab side-chain [4,5], and for the construction of templates and multifunctionalized resins for combinatorial synthesis.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283.
[2] A. Aletras, et al. (1995) Int. J. Peptide Protein Res., 45, 488.
[3] L. Bourel, et al. (2000) J. Peptide Sci., 6, 264.
[4] K. Barlos, personal communication.
[5] P. Hoogerhout, et al. (1999) J. Peptide Res., 54, 436.
[6] C. Park & K. Burgess (2001) J. Comb. Chem., 3, 257.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Water (K. F.): ≤ 1.0 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1210

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
852089852075852065
description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

form

powder

form

powder

form

powder

form

powder

assay

≥95% (TLC), ≥95.0% (HPLC)

assay

≥95% (TLC), ≥95.0% (HPLC)

assay

≥90.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

assay

≥95.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

functional group

amine

functional group

amine

functional group

amine

functional group

amine

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200


Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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