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8.52131

Fmoc-Trp(Boc)-OPfp

Novabiochem®

Synonym(s):

Fmoc-Trp(Boc)-OPfp, N-α-Fmoc-N-in-t.-Boc-L-tryptophan pentafluorophenyl ester

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About This Item

Empirical Formula (Hill Notation):
C37H29F5N2O6
CAS Number:
Molecular Weight:
692.63
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22
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Quality Segment

product line

Novabiochem®

assay

≥95.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

Boc, Fmoc

storage temp.

15-25°C

SMILES string

Fc1c(c(c(c(c1F)F)OC(=O)[C@@H](NC(=O)OCC4c5c(cccc5)c6c4cccc6)Cc2c3c([n](c2)C(=O)OC(C)(C)C)cccc3)F)F

InChI

1S/C37H29F5N2O6/c1-37(2,3)50-36(47)44-17-19(20-10-8-9-15-27(20)44)16-26(34(45)49-33-31(41)29(39)28(38)30(40)32(33)42)43-35(46)48-18-25-23-13-6-4-11-21(23)22-12-5-7-14-24(22)25/h4-15,17,25-26H,16,18H2,1-3H3,(H,43,46)/t26-/m0/s1

InChI key

IDYZGIYCOLJXRE-SANMLTNESA-N

General description

Pre-formed pentafluorophenyl ester for coupling of tryptophan amino-acid residues by Fmoc SPPS. Use enables bromophenol blue monitoring of amide bond formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in chloroform): -19.0 - -16.0 °
Purity (TLC (0004)): <5% DCU
Assay (HPLC, area%): ≥ 95.0% (a/a)
Solubility (0.5 mmole in 3 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1535

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Skin Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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