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8.55068

Hydroxymethyl polystyrene

100-200 mesh, 1% DVB, Novabiochem®

Synonym(s):

Polystyrene-CH 2OH (100-200 mesh)

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5 g
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$78.90
25 g
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$313.00

About This Item

UNSPSC Code:
13111023
NACRES:
NA.22

$78.90


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Product Name

Hydroxymethyl polystyrene (100-200 mesh), 1% DVB, Novabiochem®

Quality Segment

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Boc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

alcohol

storage temp.

2-30°C

General description

This resin is ideal for the solid phase immobilization of carboxylic acids. Less cross-linking is observed than with Merrifield resin during the attachment of diacids [1]. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines [2]. Release of carboxylic acids from this support is normally effected by treatment of the resin with H For TFMSA, or by hydrogenolysis [3]. Alcohols can be liberated by reduction with DIBAL [4] or LiBH4[5]. Methyl esters can be produced by transesterification with MeONa [6] or Ti(OEt)4/CH3CO2Me [7]. Carboxamides are also accessible via Lewis acid catalyzed aminolysis [8].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] J. M. Goldwasser, et al. (1978) Can. J. Chem., 56,1562.
[2] D. J. Burdick, et al. (1993) Tetrahedron Lett., 34,2589.
[3] J. M. Schlatter, et al. (1977) Tetrahedron Lett., 2851.
[4] M. J. Kurth, et al. (1994) J. Org. Chem., 59,5862.
[5] J. M. Stewart & J. D. Young in ′Solid Phase Peptide Synthesis, 2nd Ed.′, Rockford, Illinois, Pierce Chemical Company, 1984, pp. 92.
[6] R. Frenette, et al. (1994) Tetrahedron Lett., 35,9177.
[7] L. T. Tietze & A. Steinmetz (1996) Angew. Chem. Int. Ed.Engl., 35, 651.
[8] D. R. Barn, et al. (1996) TetrahedronLett., 37, 3213.

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 1.60 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Other Notes

Replaces: 01-64-0110

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
855079855020855115
description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis, reactivity: alcohol reactive

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

functional group

alcohol

functional group

-

functional group

amine

functional group

amine

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-30°C


Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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