8.55104
2-(4-Bromomethylphenoxy)ethyl polystyrene HL
Novabiochem®
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Check Cart for Availability | $481.00 $360.75 |
25 g | Check Cart for Availability | $1,950.00 |
About This Item
NACRES:
NA.22
UNSPSC Code:
13111023
$360.75
List Price$481.00Save 25%Web-Only Promotion
Check Cart for Availability
Quality Segment
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-8°C
General description
This versatile support is an excellent tool for the solid phase immobilization of carboxylic acids, amines and alcohols. Acids are attached by treating the resin with the appropriate DIPEA salt in DMF in the presence of CsI [1,2]. Reaction with aryl and alkyl amines provides resin-bound secondary amines. These can be readily acylated to give sulfonamides or anilides that can be cleaved with 95% TFA. Since this resin does not contain a benzylic ether linkage, it gives cleaner products than similar supports derived from Wang resin, free from impurities arising from breakdown of the linker. For examples using a similar resin, please see [1,2,3,4].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] J. W. Corbett, et al. (1997) Bioorg. Med. Chem. Lett., 7,1371.
[2] G. A. Morales, et al. (1998) J. Org. Chem., 63,1172.
[3] K. Ngu & D. V. Patel (1997) Tetrahedron Lett., 38, 973.
[4] B. Raju & T. P. Kogan (1997) Tetrahedron Lett., 38, 4965.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] J. W. Corbett, et al. (1997) Bioorg. Med. Chem. Lett., 7,1371.
[2] G. A. Morales, et al. (1998) J. Org. Chem., 63,1172.
[3] K. Ngu & D. V. Patel (1997) Tetrahedron Lett., 38, 973.
[4] B. Raju & T. P. Kogan (1997) Tetrahedron Lett., 38, 4965.
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Swelling Volume (in DMF): lot specific result
Loading (determined by elemntal analysis of bromine): 0.80 - 1.30 mmol/g
The polymer matrix is copoly (styrene - 1 % DVB), 100 - 200 mesh
Appearance of substance (visual): beads
Swelling Volume (in DMF): lot specific result
Loading (determined by elemntal analysis of bromine): 0.80 - 1.30 mmol/g
The polymer matrix is copoly (styrene - 1 % DVB), 100 - 200 mesh
Other Notes
Replaces: 01-64-0400
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
1 of 1
This Item | |||
|---|---|---|---|
| reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Boc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: solution phase peptide synthesis, reactivity: alcohol reactive |
| product line Novabiochem® | product line Novabiochem® | product line Novabiochem® | product line Novabiochem® |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis |
| storage temp. 2-8°C | storage temp. 2-30°C | storage temp. 2-8°C | storage temp. 2-8°C |
| form beads | form beads | form beads | form beads |
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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