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8.55140

Fmoc-PAL-Linker

Novabiochem®

Synonym(s):

Fmoc-PAL-Linker

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1 g
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$95.30
5 g
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$373.00

About This Item

Empirical Formula (Hill Notation):
C29H31NO7
CAS Number:
115109-65-4
Molecular Weight:
505.56
MDL number:
MFCD00236731
UNSPSC Code:
12352209
NACRES:
NA.22

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Quality Segment

200

product line

Novabiochem®

form

solid

reaction suitability

reagent type: linker

manufacturer/tradename

Novabiochem®

mp

178-180 °C

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

N(Cc4c(cc(cc4OC)OCCCCC(=O)O)OC)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C29H31NO7/c1-34-26-15-19(36-14-8-7-13-28(31)32)16-27(35-2)24(26)17-30-29(33)37-18-25-22-11-5-3-9-20(22)21-10-4-6-12-23(21)25/h3-6,9-12,15-16,25H,7-8,13-14,17-18H2,1-2H3,(H,30,33)(H,31,32)

InChI key

ATYUCXIJDKHOPX-UHFFFAOYSA-N

General description

Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker . The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker. There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.

Associated Protocols and Technical Articles


Protocols for Loading of Peptide Synthesis Resins

Analysis Note

Color (visual): white to beige to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98.0 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
852041852338283223
Fmoc-PAL-Linker Novabiochem®

Sigma-Aldrich

855140

Fmoc-PAL-Linker

Fmoc-Lys(Fmoc)-OH Novabiochem®

Sigma-Aldrich

852041

Fmoc-Lys(Fmoc)-OH

Fmoc-thioproline Novabiochem®

Sigma-Aldrich

852338

Fmoc-thioproline

Poly(allylamine hydrochloride) Mw 40,000-150,000

Sigma-Aldrich

283223

Poly(allylamine hydrochloride)

description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

description

Mw 40,000-150,000

form

solid

form

powder

form

powder

form

solid

functional group

Fmoc

functional group

amine

functional group

Fmoc

functional group

-

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

-

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

15-25°C

storage temp.

-

mp

178-180 °C

mp

170-180 °C

mp

-

mp

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Questions

  1. In the General Description of the product Fmoc-PAL-Linker Catalog 8.55140 there are numbers for two references ([1] and [2]) but I can not either follow a link or see the references. Would it be possible to provide me the references? Thanks

    1 answer

    1. The references for the product Fmoc-PAL-Linker are as follows:

      (1) Gisin BF. 1973. The Preparation of Merrifield-Resins Through Total Esterification With Cesium Salts. Helv. Chim. Acta. 56(5): 1476-1482.
      (2) Atherton E., Logan CJ, Sheppard RC. Peptide synthesis, Part 2. Procedures for solid-phase synthesis using N(alpha)-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65-74 decapeptide. J. Chem. Soc., Perkin Trans. 1. (0): 538-546.

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