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Anti-Claudin-5 Antibody

Name: Anti-Claudin-5 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Claudin-5, Transmembrane protein deleted in VCFS, TMDVCF

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, WB

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, horse, human

species reactivity (predicted by homology)

equine (based on 100% sequence homology), ox (based on 100% sequence homology)

packaging

antibody small pack of 25 μg

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

NCBI accession no.

NP_003268

UniProt accession no.

O00501

shipped in

ambient

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CLDN5(7122)

Description

General description

Claudin-5, a transmembrane protein deleted in velo-cardio-facial syndrome (TMVCF), seems to be involved in endothelial tight junctions. Claudin-5 has been exclusively found in the cell-cell borders of endothelial cells. Lower claudin-5 levels in sinusoidal endothelial cells could lead to their dysfunction during liver injuries. Levels of claudin-5 in tumor vessels could be a potential marker for hepatocellular carcinoma prognosis. The loss of claudin-5 function has been linked to carcinogenesis.

~17 kDa observed.
Molecular weights at ~17 kDa and 62 kDa may be observed depending on phosphorylation and glycosylation effects (Ishizaki, T., et al. (2003). Experimental Cell Research. 290:275–288).

Immunogen

Epitope: Cytoplasmic Domain

KLH-conjugated linear peptide corresponding to human Claudin-5 at the cytoplasmic domain.

Application

Anti-Claudin-5 Antibody detects level of Claudin-5 & has been published & validated for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:800 dilution from a representative lot detected Clausin-5 in prostate tissue.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Biochem/physiol Actions

This antibody recognizes Claudin-5 at the cytoplasmic domain.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human lung tissue lysate

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected Claudin-5 in 10 µg of human lung tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4502981	ABT47	SAB4500437
Sigma-Aldrich ABT45 Anti-Claudin-5 Antibody	Sigma-Aldrich SAB4502981 Anti-Claudin 5, C-Terminal antibody produced in rabbit	Sigma-Aldrich ABT47 Anti-Claudin-7 Antibody	Sigma-Aldrich SAB4500437 Anti-Claudin 7 antibody produced in rabbit
description from rabbit, purified by affinity chromatography	description affinity isolated antibody	description from rabbit, purified by affinity chromatography	description affinity isolated antibody
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
shipped in ambient	shipped in wet ice	shipped in wet ice	shipped in wet ice
Gene Information human ... CLDN5(7122)	Gene Information human ... CLDN5(7122)	Gene Information human ... CLDN7(1366)	Gene Information human ... CLDN7(1366)

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number

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