SCC430
ALMC-1 Plasma Cell Myeloma Cell Line
別名:
ALMC1
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この商品について
NACRES:
NA.81
UNSPSC Code:
41106514
Growth mode:
N/A
Manufacturer/tradename:
Millipore
現在、価格および在庫状況を閲覧できません。
packaging
vial of ≥1X10⁶ cells/vial mg
Quality Segment
manufacturer/tradename
Millipore
growth mode
N/A
technique(s)
cell analysis: suitable
shipped in
liquid nitrogen
storage temp.
−196°C
Application
Each vial contains >1X106 viable cells.
Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
Cells are negative for mycoplasma contamination.
Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
Cells are negative for mycoplasma contamination.
Primary systemic amyloidosis is a plasma cell disease characterized by deposition of misfolded immunoglobulin (Ig) light chain products as amyloid fibrils throughout vital tissues and organs. Amyloidosis may present as a range of symptoms, including nervous system dysfunction, swelling, fatigue, and pain in the extremities (1). Patients with amyloidosis often suffer from other plasma cell diseases such as multiple myeloma, making the study of amyloidosis and development of potential targeted treatments extremely challenging.ALMC-1 was the first plasma cell amyloidosis cell line isolated and is characterized by c-myc amplification and deletion of the tumor suppressor p53 (2). The Ig lambda secreted by ALMC-1 cells has been shown to form amyloid fibrils in vitro (2). ALMC-1 cells proliferate in presence of IL-6, a critical factor supporting tumor growth in the bone marrow microenvironment (2). ALMC-1 cells are hypotetraploid, express CD44, and overexpress the oncogene MAFB (2). The ALMC-1 plasma cell myeloma cell line represents a valuable and clinically relevant model for amyloidosis and studies of the mechanisms of myeloma progression. SourceThe ALMC-1 cell line was isolated from bone marrow of a 50-year old female patient with amyloidosis and later diagnosed with multiple myeloma (3).References1. J Am Coll Cardiol 2016; 68(12): 1323-1341.2. Blood 112 Suppl 2008; 1: 2732a-2832a.3. Cancer Res 1993; 53:5320-5327.
Features and Benefits
The ALMC-1 plasma cell myeloma cell line is a clinically relevant model for amyloidosis and studying the mechanisms of myeloma progression.
Preparation Note
The cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Other Notes
Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact licensing@milliporesigma.com.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
保管分類
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Substances Subject to be Indicated Names
ishl_indicated
Substances Subject to be Notified Names
ishl_notified
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。