SCT059
BioTracker TiY Vimentin Live Cell Dye
Live cell imaging probe for identifying tumor initiating cells (TICs) in a variety of epithelial cancers, including lung cancer. The TiY probe binds to vimentin expressed in TICs.
Synonym(s):
Live cell imaging probe, Tumor Initiating Cell (TIC) dye
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Estimated to ship onAugust 17, 2026 | $466.00 |
About This Item
$466.00
Estimated to ship onAugust 17, 2026Details
assay
≥98% (H-NMR), ≥98% (HPLC), ≥98% (LC/MS), ≥98% (elemental analysis)
technique(s)
cell based assay: suitable
detection method
fluorometric
General description
BioTracker TiY Vimentin is a live cell fluorescent dye that selectively stains TICs over differentiated tumor cells or normal cells. TiY can be used for visualization and enrichment of functionally active TICs from patient tumors. TiY displays better selectivity for tumorigenic cells than a CD166 antibody and can be used for TiY-staining-based cell sorting for TICs in various types of cancer (lung, CNS, melanoma, breast, renal, ovarian, colon and prostate cancer). At high concentrations, TiY shows selective anti-TIC activity over non-TIC and normal tissue cells.
Spectral Properties
Absorbance: 553 nm
Emission: 573 nm
References
Lee Y et al. Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2851-2854.
Application
Cell Imaging
Live Cell Dye
Physical form
Preparation Note
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Analysis Note
Molar Mass: 541.87 g/mol
Other Notes
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| description Live cell imaging probe for identifying tumor initiating cells (TICs) in a variety of epithelial cancers, including lung cancer. The TiY probe binds to vimentin expressed in TICs. | description Live cell imaging dye that measures cystine uptake at the single cell level used to detect glutathione (GSH) synthesis, reactive oxygen species (ROS) detoxification, T-cell activation and B-cell development. | description Live cell imaging dye for singlet oxygen (1O2) localized to mitochondria. Singlet oxygen is important in the field of cancer therapy, photodynamic medicine and other skin treatments. | description Live cell imaging dye for cellular nitric oxide (NO) localized to mitochondria and lysosome, used as an indicator of host defense, homeostasis and developmental functions. |
| technique(s) cell based assay: suitable | technique(s) cell based assay: suitable | technique(s) cell based assay: suitable | technique(s) cell based assay: suitable |
| assay ≥98% (H-NMR), ≥98% (LC/MS), ≥98% (HPLC), ≥98% (elemental analysis) | assay ≥98% (H-NMR), ≥98% (HPLC), ≥98% (LC/MS), ≥98% (elemental analysis) | assay ≥98% (H-NMR), ≥98% (HPLC), ≥98% (LC/MS), ≥98% (elemental analysis) | assay ≥98% (H-NMR), ≥98% (HPLC), ≥98% (LC/MS), ≥98% (elemental analysis) |
| detection method fluorometric | detection method fluorometric | detection method fluorometric | detection method fluorometric |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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