2°C to 25°C, protected from light. Freezing does not adversely affect this product. If stored refrigerated, equilibrate to room temperature for approximately 5 minutes before use.
Reconstitution: Dissolve in Tween 80 at 45 mg/mL, then dilute with a 15.25% (v/v) absolute ethanol in water solution (2 mL product in Tween 80, diluted with 6 mL ethanol/water). Under these conditions, the reconstituted solution remains physically stable with no visible precipitation for at least 12 hours at room temperature.
01885
Docetaxel
purum, ≥97.0% (HPLC)
Synonym(s):
Docetaxel anhydrous
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Available to ship TODAYfromMILWAUKEE | $304.00 |
25 mg | Available to ship TODAYfromMILWAUKEE | $1,040.00 |
About This Item
Empirical Formula (Hill Notation):
C43H53NO14
CAS Number:
Molecular Weight:
807.88
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
51101929
MDL number:
$304.00
Available to ship TODAYDetails
Subscriptions are currently unavailable.
Ships Every 4 weeks
grade
purum
Quality Segment
assay
≥97.0% (HPLC)
form
powder or crystals
impurities
~6% water
mp
186-192 °C (dec.)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
SMILES string
[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c6ccccc6
InChI
1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
InChI key
ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Gene Information
General description
Docetaxel is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree , with a baccatin ring , and is an anthracycline antibiotic. It is related to paclitaxel but structurally it differs from paclitaxel on the 3′ position of the side chain and 10′ position of the baccatin ring.
Application
Docetaxel has been used:
- to test its effect on lysosomal autophagic flux in gastric cancer cells
- in combination with stearidonic acid (SDA) to increase its efficacy and enhancing cell death in human prostate cancer cells
- as a microtubule-stabilizing agent in prostate and cervical cancer cells
- in combination with a γ-secretase inhibitor (GSI) in prostate cancer stem-like cells (PCSCs) to test its effect on the notch signaling pathway
Biochem/physiol Actions
Docetaxel (DOC) is an anti-microtubule agent , a standard anti-cancer drug used in first-line chemotherapy treatment in many types of cancer including prostate and breast cancer. It elicits a stronger effect of inhibiting angiogenesis in both in vitro and in vivo by acting on vascular endothelial growth factor (VEGF) associated with tumor cells. Being involved in many key cellular processes such as cell cycle, angiogenesis, and gene expression; docetaxel interacts with many signaling pathways, such as the epidermal growth factor receptor (EGFR) pathway, Ras pathway, etc.
Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
This Item | |||
|---|---|---|---|
| description purum, ≥97.0% (HPLC) | description Pharmaceutical Secondary Standard; Certified Reference Material | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard |
| assay ≥97.0% (HPLC) | assay - | assay - | assay - |
| form powder or crystals | form - | form - | form - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| application(s) metabolomics | application(s) pharmaceutical | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| impurities ~6% water | impurities - | impurities - | impurities - |
| grade purum | grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
signalword
Danger
Hazard Classifications
Eye Irrit. 2 - Lact. - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
-
Could youplease provide the recommended long-term storage conditions for the 25 mg lyophilized docetaxel powder upon arrival? In addition, could you please provide the appropriate solvent to use for reconstitution?
1 answer-
Helpful?
-
-
What concentration should Docetexal be reconstituted at and using which solvent?
1 answer-
The product is practically insoluble in water. Based on available data, this material may be reconstituted in DMSO at approximately 8 mg/mL, Tween 80 at >45 mg/mL, and ethanol at 50 mg/mL. Various sources report that this compound is also soluble in Chloroform, however no concentration is provided. Solutions prepared in polysorbate 80/Tween® 80 have reportedly been further diluted in a 15.25% (w/v) alcohol-in-water solution. The stability of this material in solution has not been determined. Other sources report that a 1mg/mL stock solution in DMSO may be stored at -20 °C. As a general practice, stored frozen stock solutions in working aliquots, avoid repeated freeze/thaw cycles.
Helpful?
-
-
How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
-
-
How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
-
-
Is docetaxel, product code 01885, suitable for injection into the mouse model?
1 answer-
This product is intended for research use only. It is not suitable for human or veterinary use. The material has not been tested for in vivo use. The end user would need to determine suitability. Solutions intended for use in animal models would require sterile filtration prior to administration.
Helpful?
-
-
Is Docetaxel, Product O1885, suitable for drug use?
1 answer-
No, this product is for Research use only.
Helpful?
-