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04725

3-Hydroxyglutaric acid

analytical standard

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Synonym(s):

β-Hydroxyglutaric acid, 3-Hydroxypentanedioic acid

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10 mg

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$226.00
50 mg

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$1,040.00

About This Item

Empirical Formula (Hill Notation):
C5H8O5
CAS Number:
Molecular Weight:
148.11
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
1705476

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grade

analytical standard

Quality Segment

assay

≥95.0% (GC)

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

2-8°C

InChI

1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)

InChI key

ZQHYXNSQOIDNTL-UHFFFAOYSA-N

Biochem/physiol Actions

3-Hydroxyglutaric acid is a glutaric acid derivative which is the byproduct of glutaric acidemia type I. Glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency) is an inborn error of metabolism that usually manifests in infancy by an acute encephalopathic crisis and often results in permanent motor handicap. Studies indicate that 3-hydroxyglutaric acid can be used as biomarker for GCDH (glutaryl-CoA dehydrogenase) deficiency. It is believed that the excretion of 3-hydroxyglutaric acid is increased during ketosis, which occurs during glutaryl-CoA dehydrogenase deficiency. Studies on striatal cultures show that IGF-1 and FGF-2 (bFGF) reduces 3-hydroxyglutaric acid toxicity in striatal neurons.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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This Item
H837816689890790
description

analytical standard

description

≥95% (GC)

description

95%

description

≥98.0% (GC)

format

neat

format

-

format

-

format

-

grade

analytical standard

grade

-

grade

-

grade

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

assay

≥95.0% (GC)

assay

≥95% (GC)

assay

95%

assay

≥98.0% (GC)

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-


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Storage Class

11 - Combustible Solids

wgk

WGK 3



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