This product has very limited solubility in water, rates of approximately 80 ug/mL are reported in the literature. This material is soluble in 0.1 N HCl at 25 mg/mL. Stock solutions are typically diluted in aqueous buffers or medium. External sources indicate that stock solutions may be diluted with 5% dextrose or normal saline to a concentration of 1 – 2 mg/mL. This information has not been validated.
17850
Ciprofloxacin
≥98% (HPLC)
Ciprofloxacin
Synonym(s):
1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, Ciprobay
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Estimated to ship TODAYfromsìså¬368 | ¥9,480 |
25 g | Estimated to ship TODAYfromsìså¬368 | ¥38,900 |
About This Item
Empirical Formula (Hill Notation):
C17H18FN3O3
CAS Number:
Molecular Weight:
331.34
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3568352
agency
EPA 1694
Quality Segment
assay
≥98% (HPLC)
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
application(s)
environmental
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
InChI
1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
InChI key
MYSWGUAQZAJSOK-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544), KCNH1(3756)
rat ... Gabra1(29705)
General description
Ciprofloxacin is a second-generation broad-spectrum fluoroquinolone antibiotic with extensive antimicrobial and pharmacokinetic properties that is widely used to combat bacterial infections. Its chemical name is 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid.
Chemical structure: fluoroquinolone
Chemical structure: fluoroquinolone
Application
Ciprofloxacin is widely used in clinical practices against Gram-positive and Gram-negative bacteria and the treatment of a broad range of infections, including those of the skin, eyes, urinary tract, lower respiratory tract, gastrointestinal tract, et cetera. It can also be combined with various antimicrobial agents to combat bacterial biofilms as well as multidrug-resistant microorganisms. Its derivatives have been developed to synthesize novel antibacterials with enhanced potency and diverse antimicrobial effects including antibacterial, antifungal, anti-HIV, anti-tumor, and anti-TB properties.
Biochem/physiol Actions
The mechanism of action of Ciprofloxacin is the inhibition of bacterial DNA synthesis by blocking the subunit A of DNA gyrase enzyme as well as by affecting the bacterial cell wall.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description VETRANAL®, analytical standard | description European Pharmacopoeia (EP) Reference Standard | description United States Pharmacopeia (USP) Reference Standard |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder or crystals | form - | form - | form - |
| application(s) environmental | application(s) agriculture | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| Gene Information human ... CYP1A2(1544), KCNH1(3756) | Gene Information - | Gene Information - | Gene Information - |
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Storage Class
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
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What is the ratio used to dilute ciprofloxacin in saline solution? 0.05 g in 10 ml?
1 answer-
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can we use analytical grade ciprofloxacin in patients
1 answer-
This product is intended for research use only. Unfortunately, there is not a pharmaceutical grade Ciprofloxacin product currently offered. Unless otherwise stated this product is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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is this the anhydrous form of ciprofloxacin?
1 answer-
This product is not tested for moisture content.
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Is Ciprofloxacin HCL available and is it USP grade?
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Product 17850 has a molecular formula of C17H18FN3O3. The form of the chemical being searched for would have a molecular formula of C17H18FN3O3.HCL,H2O. There is Ciprofloxacin HCL.H2O but only in very small quantities as a secondary pharmaceutical standard, with the catalog number PHR1044. Regarding the question about whether the products are USP grade, the answer is no. Both products are labeled as strictly for Research Use Only and, as such, are not suitable for human use.
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Hi. Should I keep ciprofloxacin 17850-5g in refrigerator or -20? Thank you
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In the powder form, this product is to be stored at tightly closed at room temperature. Solutions prepared in 1% HCl at 1 mg/ml may be stored in frozen aliquots at -20 °C for up to 12 months.
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What are the storage conditions of this product?
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This product is to be stored at room temperature.
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17850 Sigma-Aldrich Ciprofloxacin How much is the measured water content and active fraction of the above product?
1 answer-
This product is not tested for moisture content or potency/activity. The minimum purity of this product is 98% by HPLC. A similar product, PHR1167, is tested for loss on drying, but not potency/activity. This product typically demonstrates a >99% purity as compared to the USP and EP standards. See the link below to review this product option:
https://www.sigmaaldrich.com/US/en/product/sial/phr1167Helpful?
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If a stock solution of Cipro 17850 is solved in 0,1 HCl, at what temperature should it be stored and how long ist it stable?
1 answer-
Unfortunately, stability studies have not been performed on this product. However, several papers have information on the solution stability of ciprofloxacin.
(1) Stock solutions of ciprofloxacin in water at 200 mg/L, 100 mg/L, 40 mg/L, 20 mg/L and 4 mg/L can be stored at -20 °C for "at least 60 days.
http://www.clinchem.org/cgi/reprint/31/5/684.pdf
(2) Stock solutions of ciprofloxacin at 1 mg/mL in 1% HCl can be stored at -20 °C for at least 12 months.
http://onlinelibrary.wiley.com/doi/10.1002/bmc.1523/fullHelpful?
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Is ciprofloxacin 17850 soulable in water
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This product is soluble in DMSO (<1 mg/ml at 25° C), methanol, 0.1N hydrochloric acid (25 mg/ml), and ethanol (<1 mg/ml at 25° C). It is insoluble in water.
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Can Product 17850, Ciprofloxacin, be used in cell culture?
1 answer-
We have not done cell culture testing with this product.
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