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29208

(N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide

for protein sequence analysis (by MALDI-MS), 98%

Synonym(s):

N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide, TMPP-Ac-OSu

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Size/SKUAvailabilityPrice
50 mg

Available to ship TODAYfromMILWAUKEE

$227.00

About This Item

Empirical Formula (Hill Notation):
C33H39BrNO13P
CAS Number:
226409-58-1
Molecular Weight:
768.54
NACRES:
NA.21
PubChem Substance ID:
329753320
UNSPSC Code:
41116105
MDL number:
MFCD03095505
Assay:
≥97.5% (HPLC), 98%

$227.00

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Quality Segment

assay

≥97.5% (HPLC), 98%

technique(s)

MALDI-MS: suitable

storage temp.

−20°C

SMILES string

[Br-].COc1cc(OC)c(c(OC)c1)[P+](CC(=O)ON2C(=O)CCC2=O)(c3c(OC)cc(OC)cc3OC)c4c(OC)cc(OC)cc4OC

InChI

1S/C33H39NO13P.BrH/c1-38-19-12-22(41-4)31(23(13-19)42-5)48(18-30(37)47-34-28(35)10-11-29(34)36,32-24(43-6)14-20(39-2)15-25(32)44-7)33-26(45-8)16-21(40-3)17-27(33)46-9;/h12-17H,10-11,18H2,1-9H3;1H/q+1;/p-1

InChI key

YKMSQZIYVKTUHI-UHFFFAOYSA-M

General description

N-Succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP-Ac-OSu) is an acylating reagent, and is generally used for the selective derivatization of N-terminal a-amino group of peptide. The TMPP-acetylated peptides undergo fragmentation thereby creating a-type ions, thus obtaining sequence information becomes easier, even without the usage of automated computational approach. It can be used as a labelling reagent in liquid chromatography-coupled mass spectrometry (LC-MS/MS) of N-terminal peptides, so as to improve ionization efficiency, simplify fragmentation, and retention times, thereby leading to better separation of peptides.

Application

TMPP-Ac-OSu was used for labelling peptides, in tandem mass spectrometry, done for converting arginine to ornithine, in order to improve the fragmentation pattern of peptides.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Reagent for modifying N-termial of peptides for fast atom bombardment, FAB or matrix assisted laser desorption/ionization MS, MALDI MS

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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Questions

  1. Is TMPP in solution (acetonitrile or DMF) stable when frozen?

    1 answer

    1. The stability of this product in solution has not been evaluated. The material is packaged under inert gas and is reportedly soluble in organic solvents such as Acetonitrile, methanol, DMSO, and chloroform.

      Please see the link below to a publication that indicates stock solutions prepared in Acetonitrile may be stored at -20°C for up to 48 hours:
      https://pmc.ncbi.nlm.nih.gov/articles/PMC4484849/#FN3

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