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32425

Cyclosporin A

VETRANAL®, analytical standard

Synonym(s):

Antibiotic S 7481F1, Cyclosporine

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Size/SKUAvailabilityPrice
100 mg

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$444.00

About This Item

Empirical Formula (Hill Notation):
C62H111N11O12
CAS Number:
59865-13-3
Molecular Weight:
1202.61
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754203
MDL number:
MFCD00274558
Beilstein/REAXYS Number:
3647785
eCl@ss:
25140904

$444.00

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grade

analytical standard

Quality Segment

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key

PMATZTZNYRCHOR-CGLBZJNRSA-N

Gene Information

human ... PPIA(5478)

General description

Cyclosporin A (CsA) is a fungal metabolite, a cyclic undecapeptide. It has highly specific immunosuppressive effects with low myelotoxicity, thereby making it a valuable drug in human organ transplantation. Its immunosuppressive activity is based upon its ability to inhibit early steps of T-lymphocyte activation such as lymphokine gene transcription.
Cyclosporin A has been used to:
  • Prevent rejection of kidney and liver transplants.
  • In graft versus host disease.
  • Treatment of autoimmune diseases.
  • Treatment of Schistosomiasis.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Potent immunosuppressant; inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα; blocks cytochrome c release from mitochondria.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Cyclosporin A VETRANAL®, analytical standard

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Cyclosporin A

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Sigma-Aldrich

30024

Cyclosporin A

Cyclosporin A BioReagent, from Tolypocladium inflatum, Molecular Biology, ≥95%

Sigma-Aldrich

C1832

Cyclosporin A

Cyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid

Sigma-Aldrich

C3662

Cyclosporin A

description

VETRANAL®, analytical standard

description

97.0-101.5% (on dried basis)

description

BioReagent, from Tolypocladium inflatum, Molecular Biology, ≥95%

description

from Tolypocladium inflatum, ≥95% (HPLC), solid

grade

analytical standard

grade

-

grade

Molecular Biology

grade

-

format

neat

format

-

format

-

format

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

drug transporter assay: suitable

technique(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

-

Quality Level

100

Quality Level

200

Quality Level

300

Quality Level

300

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

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Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Codes

H302,H350,H360FD

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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Certificates of Analysis (COA)

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Questions

  1. Hello, I got this product from you and wanted to confirm if you have any data regarding its stability after being aliquoted in DMSO and stored at -20ºC or any kind of other storage that you suggest. Thank you,

    1 answer

    1. Stock solutions in ethanol or DMSO should be stored at -20 °C. Cyclosporin is stable in solution if protected from light, but its concentration may drop due to adsorption to the container walls. There is no information on how long Cyclosporin A can be stored in solution.

      Online sources suggest storing solutions at -20°C for up to 3 months.

      Helpful?

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