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42575

Dehydrocostus lactone

analytical standard

Synonym(s):

(−)-Dehydrocostus lactone; Dehydrocostus lactone; Epiligulyl oxide, (3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one, Dehydro-costus lactone (6CI,7CI), Dehydrocostuslactone, Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone, [3aS-(3aα,6aα,9aα,9bβ)]-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$114.00

About This Item

Empirical Formula (Hill Notation):
C15H18O2
CAS Number:
Molecular Weight:
230.30
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
MDL number:

$114.00


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grade

analytical standard

Quality Segment

assay

≥98.0% (GC)

optical activity

[α]/D -14.0±3.0°, c = 1 in chloroform

shelf life

limited shelf life, expiry date on the label

impurities

≤2.0% water

format

neat

storage temp.

−20°C

SMILES string

C=C1CC[C@@]2([H])C(CC[C@@H]3[C@H](OC(C3=C)=O)[C@]21[H])=C

InChI

1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1

InChI key

NETSQGRTUNRXEO-XUXIUFHCSA-N

Biochem/physiol Actions

Dehydrocostuslactone (DHE) is a sesquiterpene lactone extracted from Saussurea lappa and Aucklandia lappa. The compound possess antifungal and antimycobacterial activity and exhibit a cytotoxic effect against HepG2, OVCAR-3, and HeLa cell lines.
Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine receptor signaling. The SOCS family include eight members SOCS-1 to SOCS-7 and CIS. Dehydrocostuslactone (DHE) is a sesquiterpene lactone extracted from Saussurea lappa and Aucklandia lappa. The compound possess antifungal and antimycobacterial activity and exhibit a cytotoxic effect against HepG2, OVCAR-3, and HeLa cell lines. DHE inhibits cell proliferation not only in early-stage breast cancer MCF-7 but also in more advanced stage MDA-MB-231 cancer cells, without significant effect on H184B5F5/M10 normal mammary epithelial cells. The inhibition of breast cancer cells proliferation occurs through cell cycle blockade and apoptosis. DHE inhibits cell cycle progression and cell death through SOCS-1 and SOCS-3.

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analytical standard

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description

British Pharmacopoeia (BP) Reference Standard

grade

analytical standard

grade

primary reference standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

format

neat

format

-

format

neat

format

neat

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

assay

≥98.0% (GC)

assay

≥95.0% (HPLC)

assay

-

assay

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

limited shelf life, expiry date on the label

optical activity

[α]/D -14.0±3.0°, c = 1 in chloroform

optical activity

-

optical activity

-

optical activity

-


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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