S-Methyl methanethiosulfonate (MMTS) is commonly used to modify and block thiol groups in proteins. To achieve effective blocking of thiol groups with MMTS, the following ranges should be considered:
pH: Reactions with MMTS are typically performed in buffers with a pH range of 7-8.
Temperature: Blocking of Thiols can be carried out at room temperature (25 °C).
A literature search is encouraged to determine the best conditions for specific applications.
64306
S-Methyl methanethiosulfonate
purum, ≥98.0% (GC)
Synonym(s):
S-Methyl thiomethanesulfonate, MMTS
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| Size/SKU | Availability | Price |
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1 mL | Available to ship TODAYfromMILWAUKEE | $51.20 |
10 mL | Check Cart for Availability | $238.00 |
About This Item
Linear Formula:
CH3SO2SCH3
CAS Number:
Molecular Weight:
126.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
220-970-0
Beilstein/REAXYS Number:
1446059
MDL number:
Assay:
≥98.0% (GC)
grade
purum
Quality Segment
assay
≥98.0% (GC)
refractive index
n
bp
69-71 °C/0.4 mmHg (lit.)
solubility
chloroform: 750mg + 5 ml Chloroform mg/mL, colorless to light greenish-yellow
density
1.337 g/mL at 20 °C, 1.337 g/mL at 25 °C (lit.)
functional group
disulfide
storage temp.
2-8°C
SMILES string
CSS(C)(=O)=O
InChI
1S/C2H6O2S2/c1-5-6(2,3)4/h1-2H3
InChI key
XYONNSVDNIRXKZ-UHFFFAOYSA-N
Application
- Modification of Thiol Enzymes: S-methyl methanethiosulfonate (MMTS) offers a unique method for the modification of thiol enzymes and redox-regulated proteins, providing potential applications in biochemical research focused on enzyme regulation and redox biology (Makarov et al., 2019).
- Sensor Development for Protease Activity: S-methyl methanethiosulfonate is used as a blocking reagent on the structural transitions of papain-like cysteine proteases, which supports its utility in sensor development, allowing for the detection and analysis of protease activity in various biological processes (Markovic et al., 2023).
- Agricultural Pathogen Control: Research evaluating S-methyl methanethiosulfonate as a late blight inhibitor highlights its potential as a broad-range toxin against plant pathogens, suggesting applications in agriculture for the management of crop diseases (Joller et al., 2020).
Other Notes
Disclaimer
may discolor to yellow on storage
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This Item | |||
|---|---|---|---|
| description purum, ≥98.0% (GC) | description 97% | description 97 atom % 13C, 97% (CP) | description ≥96.0% (GC) |
| assay ≥98.0% (GC) | assay 97% | assay 97% (CP) | assay ≥96.0% (GC) |
| solubility chloroform: 750mg + 5 ml Chloroform mg/mL, colorless to light greenish-yellow | solubility DMF: soluble 1:1, chloroform: soluble 200 ul per mL, clear, faintly yellow-green, water: soluble 1:5 | solubility - | solubility - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| refractive index n | refractive index n | refractive index - | refractive index - |
| bp 69-71 °C/0.4 mmHg (lit.) | bp 69-71 °C/0.4 mmHg (lit.) | bp 69-71 °C/0.4 mmHg (lit.) | bp - |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
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Hazard Classifications
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Storage Class
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What is the temperature and pH range that this product effectively blocks thiol groups?
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What is the solubility of Product 64306, S-Methyl methanethiosulfonate?
1 answer-
Product 64306, S-Methyl methanethiosulfonate, is practically insoluble in water. It is soluble in methylene chloride. Several references do report that S-Methyl methanethiosulfonate is soluble in isopropanol at a 200mM concentration. References are provided below: 1. Yan, W., et al., "Quantitative Proteomic Analysis to Profile Dynamic Changes in the Spatial Distribution of Cellular Proteins", in Methods in Molecular Biology, Vol. 432: Organelle Proteomics, pp. 389-401 (Humana Press, 2008).2. Sadowski, P.G., et al., Quantitative proteomic approach to study subcellular localization of membrane proteins. Nature Protocols, 1, 1778-1789 (2006).
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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