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MilliporeSigma

68069

Hippuric acid

analytical standard

Synonym(s):

N-Benzoylglycine, Benzoylaminoacetic acid

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50 MG

$180.00

$180.00

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About This Item

Linear Formula:
C6H5CONHCH2COOH
CAS Number:
495-69-2
Molecular Weight:
179.17
EC Number:
207-806-3
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
1073987
MDL number:
MFCD00002692

Key Documents

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Product Name

Hippuric acid, analytical standard

InChI

1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)

InChI key

QIAFMBKCNZACKA-UHFFFAOYSA-N

SMILES string

OC(=O)CNC(=O)c1ccccc1

grade

analytical standard

assay

≥97.5% (GC)

shelf life

limited shelf life, expiry date on the label

mp

187-191 °C (lit.)

application(s)

clinical testing

format

neat

Quality Level

100

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This Item
1120038.20649328014
Hippuric acid analytical standard

Supelco

68069

Hippuric acid

Hippuric acid 98%

Sigma-Aldrich

112003

Hippuric acid

Hippuric acid for synthesis

Sigma-Aldrich

8.20649

Hippuric acid

3-Methylhippuric acid 98%

Sigma-Aldrich

328014

3-Methylhippuric acid

format

neat

format

-

format

-

format

-

grade

analytical standard

grade

-

grade

-

grade

-

assay

≥97.5% (GC)

assay

98%

assay

≥97.5% (acidimetric)

assay

98%

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

mp

187-191 °C (lit.)

mp

187-191 °C (lit.)

mp

188-190 °C

mp

138-140 °C (lit.)

application(s)

clinical testing

application(s)

peptide synthesis

application(s)

-

application(s)

-

Application

Hippuric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Human biological fluids using high-performance liquid chromatography (HPLC) with UV detection.[1]
  • Human and rat urine samples using gas chromatography–mass spectrometry (GC–MS).[2]
  • Human urine samples using GC equipped with a flame ionization detector.[3]

General description

Hippuric acid, the glycine conjugate of benzoic acid, is formed via a biotransformation process.[1] From scientific literature, it is reported to be found as an excretory product in urine. Hippuric acid is also known to be catabolically synthesized from benzene-type aromatic compounds, believed to be originated from various factors such as environmental exposures, basic human liver metabolism of protein catabolism, cyclic sugar type-compounds, quinic acid, etc.[4]

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN3732
BCCL5594
BCCM2515
BCCK8243
BCCG4182

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Determination of benzoic acid and hippuric acid in human plasma and urine by high-performance liquid chromatography
Kubota K, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 425, 67-75 (1988)
Simultaneous determination of urinary hippuric acid, o-, m-and p-methylhippuric acids, mandelic acid and phenylglyoxylic acid for biomonitoring of volatile organic compounds by gas chromatography-mass spectrometry.
Ohashi Y, et al.
Analytica Chimica Acta, 566(2), 167-171 (2006)
Ronald W Pero
Current clinical pharmacology, 5(1), 67-73 (2009-11-07)
Hippuric acid has been a major human metabolite for years. However, there is no well-known documented health benefit associated with it except for excretion of environmental-toxic exposures of aromatic compounds such as toluene, or from dietary protein degradation and re-synthesis
P Kongtip et al.
Journal of chromatography. B, Biomedical sciences and applications, 751(1), 199-203 (2001-03-10)
A modified method for the simultaneous determination of hippuric acid (HA) and o-, m- and p-methylhippuric acids (o-, m- and p-MHAs) in urine is described. These metabolites were extracted, derivatized into their methyl ester derivatives and analyzed using a gas

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