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72345

Nicotinamide

synthetic, ≥98.5% (HPLC), PARP inhibitor, powder

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Synonym(s):

Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP

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Size/SKUAvailabilityPrice
50 g

Available to ship TODAY

$36.90
250 g

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$63.60

About This Item

Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
Molecular Weight:
122.12
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
202-713-4
MDL number:
Beilstein/REAXYS Number:
383619
Assay:
≥98.5% (HPLC)
Form:
powder

$36.90

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Product Name

Nicotinamide, ≥98.5% (HPLC)

biological source

synthetic

Quality Segment

assay

≥98.5% (HPLC)

form

powder

color

colorless to white

mp

128-131 °C

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

General description

Nicotinamide is synthesized in the liver from nicotinic acid. It is also produced as a result of nicotinamide adenine dinucleotide (NAD+) hydrolysis.

Application

Nicotinamide has been used:
  • as a precursor to study its effect on nicotinamide adenine dinucleotide (NAD) concentration in NAD-deficient mammalian mitochondria
  • as an inhibitor of sirtuin (SIRT) family of deacetylases in in vitro serine hydroxymethyltransferase 2 (SHMT2) deacetylation assay
  • to study its effect on ischemia-reperfusion (I-R) injury-induced cell death in ptenαm/m mice

Biochem/physiol Actions

Nicotinamide serves as a precursor for β-nicotinamide adenine dinucleotide (NAD+) coenzyme production. It is involved in the synthesis of NAD+ phosphate (NADP+). It also regulates the mechanism of cell survival and cell death. Fatigue, skin pigmentation, decreased appetite and mouth ulcers are indications of nicotinamide deficiency. Its chronic deficiency can lead to pellagra. Nicotinamide is known to show protective effects on oxidative stress.
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

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This Item
72340N3376N0636
description

≥98.5% (HPLC)

description

≥99.5% (HPLC)

description

≥98% (HPLC), powder

description

BioReagent, suitable for cell culture, suitable for insect cell culture

assay

≥98.5% (HPLC)

assay

≥99.5% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder or crystals

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

colorless to white

color

colorless to white

color

white

color

white

biological source

synthetic

biological source

synthetic

biological source

-

biological source

synthetic (organic)

mp

128-131 °C

mp

128-131 °C

mp

128-131 °C (lit.)

mp

128-131 °C (lit.)


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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

302.0 °F - closed cup

Flash Point (°C)

150 °C - closed cup

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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