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I3377

Isoniazid

analytical standard, ≥99% (TLC)

Synonym(s):

4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide

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5 g

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$20.10
$17.08
50 g

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$103.00
$77.25
250 g

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$205.00

About This Item

Empirical Formula (Hill Notation):
C6H7N3O
CAS Number:
Molecular Weight:
137.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-214-6
Beilstein/REAXYS Number:
119374
MDL number:

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grade

analytical standard

Quality Segment

assay

≥99% (TLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

171-173 °C (lit.)

fluorescence

λex 360 nm; λem 450 nm (thiol adduct)

antibiotic activity spectrum

mycobacteria

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

NNC(=O)c1ccncc1

InChI

1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

InChI key

QRXWMOHMRWLFEY-UHFFFAOYSA-N

General description

Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.
Chemical structure: pyridine

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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This Item
PHR1932I0500000BP1083
Isoniazid British Pharmacopoeia (BP) Reference Standard

BP1083

Isoniazid

description

analytical standard, ≥99% (TLC)

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

grade

analytical standard

grade

pharmaceutical secondary standard, certified reference material

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

format

neat

format

-

format

neat

format

neat

mp

171-173 °C (lit.)

mp

171-173 °C (lit.)

mp

171-173 °C (lit.)

mp

171-173 °C (lit.)

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule


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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How do I prepare a 10mL solution of the drug at a concentration of 10mg/mL

    1 answer
    1. 100 mg of material would need to be dissolved in 10 total mL of solvent. Solubility is tested at 50 mg/mL in water, so water is suitable at this concentration. It should also be soluble in ethanol up to 20 mg/mL or so, but this is not tested or guaranteed by us. Please keep in mind that this is an R&D-grade material intended for use as an analytical standard - not for use as a drug for human or animal application.

      Helpful?

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