Stock solutions should be sterile filtered and stored at 2-8°C. Stock solutions are stable at 37°C for 5 days. For more detailed information on a specific application, a literature search is recommended.
P0972
Polymyxin B sulfate
meets USP testing specifications
Synonym(s):
Polymyxin B sulfate salt
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| Size/SKU | Availability | Price |
|---|---|---|
1000000 units | Available to ship TODAYfromMILWAUKEE | $95.90 |
10000000 units | Available to ship TODAYfromMILWAUKEE | $475.00 |
50000000 units | Available to ship TODAYfromMILWAUKEE | $1,680.00 |
About This Item
Empirical Formula (Hill Notation):
C55H96N16O13 · 2H2SO4
CAS Number:
Molecular Weight:
1385.61
UNSPSC Code:
12352209
NACRES:
NA.21
EC Number:
215-774-7
MDL number:
Quality Segment
agency
USP/NF, meets USP testing specifications
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, fungi
application(s)
pharmaceutical (small molecule)
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key
HNDFYNOVSOOGDU-UHFFFAOYSA-N
General description
Chemical structure: peptide
Application
Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Biochem/physiol Actions
Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Packaging
This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone.
Disclaimer
As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
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This Item | |||
|---|---|---|---|
| description meets USP testing specifications | description Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases. | description Pharmaceutical Secondary Standard; Certified Reference Material | description European Pharmacopoeia (EP) Reference Standard |
| mode of action cell membrane | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, fungi, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level - |
| application(s) pharmaceutical (small molecule) | application(s) - | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| form powder | form solid | form - | form - |
| storage temp. 2-8°C | storage temp. 10-30°C | storage temp. 2-8°C | storage temp. - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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how do I use Polymyxin B sulfate (Molecular weight 1385.61g/mol) in 200mL of ultra-pure water ?
1 answer-
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What is MU and how does this relate to milligrams?
1 answer-
MU is million units. You can convert this to mg by dividing package size by the unit activity listed on the Certificate of Analysis for your specific lot.
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What is the solution stability of Product P0972, Polymyxin B sulfate?
1 answer-
For solution stability information, please refer to the product information sheet for a related Polymyxin B sulfate product (Product No. P1004).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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I see that you list several Polymyxin B Sulfate products (P0972, P1004, P4932, 81334 and P4119). What are the differences?
1 answer-
The primary difference between the products is the testing. Product P0972 is USP tested, product P4932 is tested against 3 mammalian cell lines to make sure it is not toxic to the cells, product P4119 is cell culture and endotoxin tested, and products P1004 and 81334 are the research grades with P1004 in USP units and 81334 in international units.
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