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PHR2091

Nicotinamide Impurity F

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1-Methylnicotinamide chloride, 3-Carbamyl-1-methylpyridinium chloride, MNA, N-Methylnicotinic acid amide chloride, N1-Methylnicotinamide chloride

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Size/SKUAvailabilityPrice
100 mg

Available to ship TODAYfromMILWAUKEE

$341.00
$255.75

About This Item

Empirical Formula (Hill Notation):
C7H9ClN2O
CAS Number:
1005-24-9
Molecular Weight:
172.61
UNSPSC Code:
41116107
NACRES:
NA.24

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Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

form

powder

packaging

pkg of 100 mg

application(s)

pharmaceutical

storage temp.

2-30°C

SMILES string

Cl.[n+]1(cc(ccc1)\C(=N\[H])\[O-])C

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

InChI key

BWVDQVQUNNBTLK-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide with antithrombotic and anti-inflammatory effects.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB9787 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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This Item
SML0704PHR2087PHR2089
Nicotinamide Impurity F Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2091

Nicotinamide Impurity F

1-Methylnicotinamide chloride ≥98% (HPLC)

Sigma-Aldrich

SML0704

1-Methylnicotinamide chloride

Nicotinamide Impurity B Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2087

Nicotinamide Impurity B

Nicotinamide Impurity D Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2089

Nicotinamide Impurity D

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

≥98% (HPLC)

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

Pharmaceutical Secondary Standard; Certified Reference Material

application(s)

pharmaceutical

application(s)

-

application(s)

pharmaceutical small molecule

application(s)

pharmaceutical small molecule

form

powder

form

powder

form

powder

form

powder

Quality Level

300

Quality Level

100

Quality Level

300

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

pharmaceutical secondary standard, certified reference material

grade

certified reference material, pharmaceutical secondary standard

storage temp.

2-30°C

storage temp.

room temp

storage temp.

2-30°C

storage temp.

2-30°C

packaging

pkg of 100 mg

packaging

-

packaging

pkg of 100 mg

packaging

pkg of 100 mg

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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