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17946

1α-Hydroxyvitamin D3

≥97.0% (HPLC)

Synonym(s):

1α-Hydroxycholecalciferol, Alfacalcidol

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Size/SKUAvailabilityPrice
1 mg
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$599.00

About This Item

Empirical Formula (Hill Notation):
C27H44O2
CAS Number:
Molecular Weight:
400.64
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352205
EC Number:
255-297-1
MDL number:

$599.00


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biological source

synthetic

Quality Segment

assay

≥97.0% (HPLC)

form

powder or crystals

color

white to off-white

storage temp.

−20°C

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C

InChI

1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1

InChI key

OFHCOWSQAMBJIW-AVJTYSNKSA-N

Gene Information

human ... VDR(7421)

General description

1α-Hydroxyvitamin D3, also known as alfacalcidol, is a synthetic vitamin D3 analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

Biochem/physiol Actions

Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.
1α-Hydroxyvitamin D3 facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
17936A0325450D1530
description

≥97.0% (HPLC)

description

≥97.0% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

≥99% (HPLC)

biological source

synthetic

biological source

-

biological source

synthetic

biological source

-

assay

≥97.0% (HPLC)

assay

≥97.0% (HPLC)

assay

-

assay

≥99% (HPLC)

form

powder or crystals

form

crystals

form

solid

form

solid

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

color

white to off-white

color

white to off-white

color

-

color

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

300


hcodes

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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