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258024

α-Tocopherol

≥95.5%

Synonym(s):

(±)-α-Tocopherol, DL-all-rac-α-Tocopherol, Vitamin E

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Pack SizeSKUAvailabilityPrice
5 g

Available to ship TODAYfromMILWAUKEE

$70.90
100 g

Estimated to ship onMay 07, 2026fromMILWAUKEE

$132.00
500 g

Estimated to ship onMay 07, 2026fromMILWAUKEE

$456.00

About This Item

Empirical Formula (Hill Notation):
C29H50O2
CAS Number:
10191-41-0
Molecular Weight:
430.71
NACRES:
NA.28
PubChem Substance ID:
57648149
eCl@ss:
34058016
UNSPSC Code:
12352205
EC Number:
233-466-0
MDL number:
MFCD00006848
Beilstein/REAXYS Number:
94012

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biological source

synthetic

Quality Level

200

assay

≥95.5%

form

liquid

technique(s)

HPLC: suitable

color

faint brown to brown, yellow to very dark yellow

density

0.950 g/mL at 20 °C (lit.)

application(s)

cell analysis

storage temp.

2-8°C

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

InChI key

GVJHHUAWPYXKBD-UHFFFAOYSA-N

General description

α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.

Application

α-Tocopherol has been used:
  • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography
  • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity
  • to assess its protective effects on acetaminophen (APAP)-mediated liver damage

Biochem/physiol Actions

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

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1 of 1

This Item
BP882T155000090669
α-Tocopherol ≥95.5%

Sigma-Aldrich

258024

α-Tocopherol

α-Tocopherol British Pharmacopoeia (BP) Reference Standard

BP882

α-Tocopherol

α-Tocopherol European Pharmacopoeia (EP) Reference Standard

T1550000

α-Tocopherol

(±)-α-Tocopherol tested according to Ph. Eur.

Sigma-Aldrich

90669

(±)-α-Tocopherol

technique(s)

HPLC: suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

biological source

synthetic

biological source

-

biological source

synthetic

biological source

synthetic

assay

≥95.5%

assay

-

assay

-

assay

96.0-102.0%

application(s)

cell analysis

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

research use (small molecule)

form

liquid

form

solid

form

solid

form

liquid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX9780
MKCW5964
MKCX1479
0000422457
0000311457

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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study
Tantavisut S, et al.
BMC Musculoskelet. Disord., 18(1), 281-281 (2017)
Nutritional deficiencies and syndromes associated with alcoholism
Textbook of Clinical Neurology (Third Edition), 897-917 (2007)
Oxidative stress induced by chlorine dioxide as an insecticidal factor to the Indian meal moth, Plodia interpunctella
Kumar S, et al
Pesticide Biochemistry and Physiology, 124, 48-59 (2015)
View All Related Papers

Global Trade Item Number

SKUGTIN
258024-100G04061838252722
258024-5G04061838090133
258024-500G04061826059708

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Could you please provide the concentration of this product (mg/ml)?

    1 answer

    1. This product is a neat or pure liquid and has not been diluted. This material has a density of 0.950 g/mL and a molecular weight of 430.71 g/mol. The minimum purity is 95.5%, thus the molarity will vary slightly from lot to lot. The molarity can range from 2.11M (95.5%) to 2.20M (100%).

      Helpful?

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