The stability of Product 27655, Colistin Sodium Methanesulfonate, if stored at ambient temperature is not determined.
27655
Colistin sodium methanesulfonate
from Bacillus colistinus
Synonym(s):
Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Estimated to ship TODAYfromMILWAUKEE | $198.00 |
5 g | Estimated to ship TODAYfromMILWAUKEE | $822.00 $616.50 |
About This Item
Empirical Formula (Hill Notation):
C58H115N16Na5O28S5
CAS Number:
Molecular Weight:
1759.90
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
232-516-9
MDL number:
biological source
Bacillus colistinus
Quality Segment
form
powder or crystals
ign. residue
~20%
loss
≤5.0% loss on drying
color
white to off-white
pH
6.5-8.5
antibiotic activity spectrum
Gram-negative bacteria
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
InChI
1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1
InChI key
WSDSONZFNWDYGZ-BKFDUBCBSA-I
General description
Chemical structure: peptide
Application
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.
Biochem/physiol Actions
Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect .
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Antimicrobial spectrum: Gram-negative bacteria.
Packaging
1g, 5g
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.
1 of 1
This Item | |||
|---|---|---|---|
| description from Bacillus colistinus | description Pharmaceutical Secondary Standard; Certified Reference Material | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard |
| mode of action cell membrane | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| form powder or crystals | form - | form solid | form - |
| biological source Bacillus colistinus | biological source - | biological source - | biological source - |
| storage temp. 2-8°C | storage temp. -10 to -25°C | storage temp. −20°C | storage temp. 2-8°C |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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For how long can product 27655 (Colistin Sodium Methanesulfonate) be stored at RT in powder form before loosing any efficacy? Can you provide any RT storage stability/efficacy data?
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