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48488

Sodium (±)-homocitrate tribasic

Synonym(s):

2-Hydroxy-1,2,4-butanetricarboxylic acid trisodium salt, Trisodium homocitrate

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About This Item

Empirical Formula (Hill Notation):
C7H7Na3O7
Molecular Weight:
272.10
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
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impurities

≤15.0% water

Quality Level

SMILES string

[Na+].[Na+].[Na+].OC(CCC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

1S/C7H10O7.3Na/c8-4(9)1-2-7(14,6(12)13)3-5(10)11;;;/h14H,1-3H2,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3

InChI key

SNTBDRNHMPWDFS-UHFFFAOYSA-K

Application

Sodium (±)-homocitrate tribasic may be used in studies of formation and function of the iron-molybdenum cofactor (FeMo-co) which contains 7Fe, 9S, Mo, R-homocitrate. FeMo-co is essential for nitrogen fixation by nitrogenous organisms.

Biochem/physiol Actions

Component of the iron-molybdenum cofactor of nitrogenases[1] [2], essential isomerization of homocitrate via homoaconitate to homoisocitrate[3], homocitrate accumulation seems to act as a sensor of lysine-pathway distress[4].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
28-2420
Quality Level

100

Quality Level

-

impurities

≤15.0% water

impurities

-


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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T R Hoover et al.
Nature, 329(6142), 855-857 (1987-10-04)
Nitrogenase catalyses the ATP-dependent reduction of N2 to NH3, and is composed of two proteins, dinitrogenase (MoFe protein or component I) and dinitrogenase reductase (Fe protein or component II). Dinitrogenase contains a unique prosthetic group (iron-molybdenum cofactor, FeMoco) comprised of
T R Hoover et al.
Biochemistry, 28(7), 2768-2771 (1989-04-04)
When apodinitrogenase (lacking FeMo-co) was activated with FeMo-co synthesized in vitro in the presence of 3H-labeled homocitrate, label was incorporated into dinitrogenase. The physical association of the label with FeMo-co was demonstrated by reisolation and purification of the cofactor from
Franco Teves et al.
Microbiology (Reading, England), 155(Pt 12), 3881-3892 (2009-08-22)
The lysine biosynthetic pathway has to supply large amounts of alpha-aminoadipic acid for penicillin biosynthesis in Penicillium chrysogenum. In this study, we have characterized the P. chrysogenum L2 mutant, a lysine auxotroph that shows highly increased expression of several lysine



Global Trade Item Number

SKUGTIN
48488-10MG04061832860268
48488-50MG04061832391816

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