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55865

Digoxigenin NHS-ester

≥80% (HPLC)

Sinonimo/i:

ε-(Digoxigenin-3-0-acetamido)caproic acid N-hydroxysuccinimide ester, DIG NHS

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Taglio della confezioneSKUDisponibilitàPrezzo
1 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
317,00 €
5 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
1.080,00 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C35H50N2O10
Numero CAS:
129273-26-3
Peso molecolare:
658.78
NACRES:
NA.25
PubChem Substance ID:
57651557
UNSPSC Code:
12352108
MDL number:
MFCD02093394
Assay:
≥80% (HPLC)
Form:
solid
Quality level:
200

317,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Quality Level

200

assay

≥80% (HPLC)

form

solid

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@@H](C2)OCC(=O)NCCCCCC(=O)ON6C(=O)CCC6=O

InChI

1S/C35H50N2O10/c1-33-13-11-23(45-20-28(39)36-15-5-3-4-6-31(42)47-37-29(40)9-10-30(37)41)17-22(33)7-8-25-26(33)18-27(38)34(2)24(12-14-35(25,34)44)21-16-32(43)46-19-21/h16,22-27,38,44H,3-15,17-20H2,1-2H3,(H,36,39)/t22-,23+,24-,25-,26+,27-,33+,34+,35+/m1/s1

InChI key

KHNDABJZSPPYLE-FUGFVFQCSA-N

Application

Digoxigenin NHS-ester has been used in the preparation of streptavidin-digoxigenin conjugate and digoxin-recombinant Ara h1 (peanut component) conjugate for enzyme-linked immunosorbent assay (ELISA) analysis.

Biochem/physiol Actions

Digoxigenin NHS-ester is an activated ester that reacts with amino groups under mild conditions, attaching the digoxigenin moiety to proteins or 5′-amino substituted oligonucleotides[1][2] Digoxigenin labeling is used to immuno-tag molecules for detection using anti-digoxigenin antibodies with high affinities and specificity.
Digoxigenin, an aglycon, is a pharmacologically active plant toxin. It is less potent than digoxin. It is used in lower doses to treat heart conditions. Digoxigenin is usually conjugated to another payload which reduces its remaining activity or accessibility to tissues. Since digoxigenin is permanently bound and entirely covered by the capture modules, it cannot be used as an active entity.

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Questo articolo
113330540011542315481
Digoxigenin NHS-ester ≥80% (HPLC)

Sigma-Aldrich

55865

Digoxigenin NHS-ester

Digoxigenin-3-O-methylcarbonyl-ε-aminocaproic acid-N-hydroxysuccinimide ester >90% (elementary analysis), pkg of 5 mg, powder, pH range 2-13

Roche

11333054001

Digoxigenin-3-O-methylcarbonyl-ε-aminocaproic acid-N-hydroxysuccinimide ester

Boc-Gly-OSu ≥99.0% (T)

Sigma-Aldrich

15423

Boc-Gly-OSu

Boc-Phe-OSu ≥98.0% (HPLC)

Sigma-Aldrich

15481

Boc-Phe-OSu

form

solid

form

powder

form

solid

form

solid

assay

≥80% (HPLC)

assay

>90% (elementary analysis)

assay

≥99.0% (T)

assay

≥98.0% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 2

Classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
BCCP2933
BCCN1891
BCCM3603
BCCM0773
BCCM0721

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R Antolovic et al.
The Journal of biological chemistry, 273(26), 16259-16264 (1998-06-20)
Searching for a binding protein in blood, which may be involved in the specific transport of cardiac glycosides to their receptor sites on the sodium pump, we isolated a cardiac glycoside-binding protein (CGBG) of 26 kDa from the globulin fraction
R Antolovic et al.
FEBS letters, 368(1), 169-172 (1995-07-10)
The digoxigenin derivative N-hydroxysuccinimidyl digoxigenin-3-O-methylcarbonyl-epsilon-aminocaproate (HDMA) has been shown to covalently label the ouabain binding site of the Na,K-ATPase epsilon subunit [Antolovic et al. (1995) Eur. J. Biochem. 227, 61-67]. In the present study we observed both, labeling and inactivation
Silke Metz et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(20), 8194-8199 (2011-05-04)
Bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) were generated for targeted payload delivery. Targeting moieties are IgGs that bind the tumor antigens Her2, IGF1R, CD22, or LeY. A Dig-binding single-chain Fv was attached in disulfide-stabilized form
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Numero articolo commerciale globale

SKUGTIN
55865-5MG-F04061832860381
55865-1MG-F04061826672495

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