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59983

Josamycin

≥90% (HPLC)

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Synonym(s):

Leucomycin A3

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Size/SKUAvailabilityPrice
50 mg

Available to ship TODAYfromMILWAUKEE

$89.40

About This Item

Empirical Formula (Hill Notation):
C42H69NO15
CAS Number:
16846-24-5
Molecular Weight:
827.99
NACRES:
NA.85
PubChem Substance ID:
57651709
UNSPSC Code:
51102829
EC Number:
240-871-6
MDL number:
MFCD00211043

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Quality Segment

assay

≥90% (HPLC)

form

powder

color

white to slightly yellow

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O

InChI

1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1

InChI key

XJSFLOJWULLJQS-NGVXBBESSA-N

General description

Chemical structure: macrolide

Application

Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Biochem/physiol Actions

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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Josamycin ≥90% (HPLC)

Sigma-Aldrich

59983

Josamycin

Josamycin European Pharmacopoeia (EP) Reference Standard

Y0000041

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Josamycin for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001315

Josamycin for peak identification

vibrant-m

Y0000042

Josamycin propionate

description

≥90% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

mode of action

protein synthesis | interferes

mode of action

-

mode of action

-

mode of action

-

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

assay

≥90% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCN5229
    BCBB9411
    BCBF0905V
    384410/1
    416679/1

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