61327
Lactoferrin from human milk
iron-saturated, ≥85% (GE)
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Acerca de este artículo
Form:
solid
Assay:
≥85% (GE)
Biological source:
human milk
Mol wt:
82.4 kDa
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Servicio técnico
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Permítanos ayudarlebiological source
human milk
Quality Level
assay
≥85% (GE)
form
solid
quality
iron-saturated
mol wt
82.4 kDa
concentration
≥0.15 % (w/w) Fe
solubility
0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown
UniProt accession no.
storage temp.
2-8°C
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Application
Lactoferrin was used for development of lactoferrin immunosensor.[1]
Biochem/physiol Actions
Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Luigi Campanella et al.
Journal of pharmaceutical and biomedical analysis, 53(2), 186-193 (2010-04-17)
The last year we fabricated some new immunosensors for the analysis of lactoferrin protein. In the present research the immunological and analytical characteristics of the immunosensor method have been extensively investigated. The study was therefore extended to cover the ability
Gregory T Spear et al.
PloS one, 6(5), e19560-e19560 (2011-05-17)
More than one million new cases of sexually transmitted diseases (STDs) occur each day. The immune responses and inflammation induced by STDs and other frequent non-STD microbial colonizations (i.e. Candida and bacterial vaginosis) can have serious pathologic consequences in women
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 61327-10MG-F | 04061833257968 |
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