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61327

Lactoferrin from human milk

iron-saturated, ≥85% (GE)

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10 mg

Estimated to ship onJuly 17, 2026fromMILWAUKEE

$235.00

About This Item

CAS Number:
936541-36-5
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00164307
Form:
solid
Assay:
≥85% (GE)
Biological source:
human milk
Mol wt:
82.4 kDa

$235.00

Estimated to ship onJuly 17, 2026Details

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biological source

human milk

Quality Level

100

assay

≥85% (GE)

form

solid

quality

iron-saturated

mol wt

82.4 kDa

concentration

≥0.15 % (w/w) Fe

solubility

0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown

UniProt accession no.

P02788

storage temp.

2-8°C

SMILES string

N([C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)O)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)N)C)CC(=O)O

InChI

1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1

InChI key

QCBUWCQOKPLTDZ-PKRULZLPSA-N

Gene Information

human ... LTF(4057)

Application

Lactoferrin was used for development of lactoferrin immunosensor.[1]

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

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Lactoferrin from human milk iron-saturated, ≥85% (GE)

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

61326

Lactoferrin from human milk

assay

≥85% (GE)

assay

≥85% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

assay

~80% (GE)

biological source

human milk

biological source

human milk

biological source

-

biological source

human milk

concentration

≥0.15 % (w/w) Fe

concentration

-

concentration

-

concentration

-

mol wt

82.4 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

form

solid

form

powder

form

powder

form

solid

solubility

0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown

solubility

phosphate buffer: 10 mg/mL at 25 °C (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4)

solubility

PBS, pH 7.4: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 °C)

solubility

H2O: 1 mg/mL, clear to very faintly hazy, colorless to faintly yellow

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK1250
BCCL0005
BCCL0783
BCBT9670
BCBN5017V

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Luigi Campanella et al.
Journal of pharmaceutical and biomedical analysis, 53(2), 186-193 (2010-04-17)
The last year we fabricated some new immunosensors for the analysis of lactoferrin protein. In the present research the immunological and analytical characteristics of the immunosensor method have been extensively investigated. The study was therefore extended to cover the ability
Gregory T Spear et al.
PloS one, 6(5), e19560-e19560 (2011-05-17)
More than one million new cases of sexually transmitted diseases (STDs) occur each day. The immune responses and inflammation induced by STDs and other frequent non-STD microbial colonizations (i.e. Candida and bacterial vaginosis) can have serious pathologic consequences in women

Global Trade Item Number

SKUGTIN
61327-10MG-F04061833257968

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