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C5429

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

Cathepsin B substrate, powder

Synonym(s):

Z-RR-AMC

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5 mg
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$98.40
25 mg
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$355.00

About This Item

Empirical Formula (Hill Notation):
C30H39N9O6
CAS Number:
136132-67-7
Molecular Weight:
621.69
UNSPSC Code:
12352209
PubChem Substance ID:
24892784
NACRES:
NA.32
MDL number:
MFCD00133576

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Product Name

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,

form

powder

Quality Segment

200

impurities

~4% isopropanol

storage temp.

−20°C

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

InChI

1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H

InChI key

HLSNWWKWVKPXKI-UHFFFAOYSA-N

Gene Information

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

General description

Fluorogenic substrate for cathepsin B.

Application

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a cathepsin B substrate in zymography analysis of protease in feces extract.[1]
  • in cathepsin B activity assay.
  • as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

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This Item
M0938C8571C9521
Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

Sigma-Aldrich

C5429

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide >97% (HPLC), solid

Sigma-Aldrich

M0938

7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide

Cathepsin B from human liver buffered aqueous solution, ≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

Sigma-Aldrich

C8571

Cathepsin B from human liver

Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride kallikrein substrate

Sigma-Aldrich

C9521

Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

powder

form

solid

form

buffered aqueous solution

form

powder

Gene Information

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

Gene Information

human ... CTSD(1509), CTSE(1510)
mouse ... CTSD(13033), CTSE(13034)
rat ... CTSD(171293), CTSE(25424)

Gene Information

human ... CTSB(1508)

Gene Information

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

impurities

~4% isopropanol

impurities

-

impurities

-

impurities

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP1267
BCCN3179
BCCL5191
BCCJ3382
BCCF1094

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Related Content

Enzymatic Assay of Cathepsin B

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

Global Trade Item Number

SKUGTIN
C5429-25MG04061833502112
C5429-5MG04061833502129

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