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Anti-DSCR1 (C-terminal) antibody produced in rabbit

Name: Anti-DSCR1 (C-terminal) antibody produced in rabbit
Brand: SIGMA
Price: 591 USD
Availability: InStock

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ADAP78, Anti-Calcipressin 1, Anti-DSC1, Anti-Down Syndrome Candidate Region 1, Anti-MCIP1, Anti-Myocyte-enriched calcineurin-interacting protein 1, Anti-RCAN1, Anti-RCN1, Anti-Regulator of calcineurin 1

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Size/SKU	Availability	Price
200 μL	Estimated to ship onOctober 26, 2026fromMILWAUKEE	$591.00

About This Item

NACRES:

NA.44

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$591.00

Estimated to ship onOctober 26, 2026Details

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Properties

Quality Segment

200

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~26 kDa

species reactivity

mouse, rat, human

concentration

~1.5 mg/mL

technique(s)

western blot: 2-4 μg/mL using HEK-293T cells expressing human DSCR1

UniProt accession no.

P53805

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RCAN1(1827)
mouse ... Dscr1(54720)
rat ... Dscr1(266766)

Description

General description

DSCR1 (Down Syndrome Candidate Region 1 is encoded by a gene mapped to human chromosome 21q22.1. DSCR1 belongs to a family of conserved proteins named regulators of calcineurin (RCAN), that in humans include RCAN, encoded by the DSCR1L1-2 genes. DSCR1 is highly expressed in the central nervous system (CNS) during early embryonic development, in heart, and in skeletal muscle.

Immunogen

Synthetic peptide corresponding to a sequence at C-terminal of human DSCR1, conjugated to KLH. This sequence is identical in human DSCR1 isoforms a and b, and rat and mouse DSCR1.

Application

Anti-DSCR1 (C-terminal) antibody produced in rabbit has been used in proximity ligation assay (PLA) and immunoblotting.

Anti-DSCR1 (C-terminal) antibody is suitable for use in western blot (2-4 μg/mL using HEK-293T cells expressing human DSCR1) and in immunoblotting (approx. 26 kDa).

Biochem/physiol Actions

Anti-DSCR1 (C-terminal) antibody is specific for DSCR1 in rats, mice and humans. The immunizing peptide specifically inhibits the staining of DSCR1 by immunoblotting.

Down Syndrome Candidate Region 1 (DSCR1) is involved in cellular adaptation to oxidative stress, and interacts with calcineurin to inhibit its phosphatase activity, thereby regulating the calcineurin- Nuclear factor of activated T-cells (NFAT) signaling pathway and affecting central nervous system (CNS) development and angiogenesis. Chronic overexpression of DSCR1 has been implicated in additional pathological conditions including Alzheimer′s disease and cardiac hypertrophy, possibly through inhibition of calcineurin activity. DSCR1 is induced by vascular endothelial growth factor (VEGF) in activated endothelial cells and regulates the expression of inflammatory marker genes such as interleukin-8 (IL-8), tissue factor, E-selectin and cyclooxygenase (Cox-2).

Down Syndrome Candidate Region 1 or DSCR1 is a candidate gene involved in the pathogenesis of Down′s Syndrome (DS). DSCR1 is usually expressed in cardiac, skeletal and brain tissues, whereas its overexpression in fetal brain tissues is associated with DS. DSCR1 inhibits calcineurin-mediated mRNA synthesis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	SAB2108705	ABN1676M	SAB6012163
Sigma-Aldrich D6694 Anti-DSCR1 (C-terminal) antibody produced in rabbit	Sigma-Aldrich SAB2108705 Anti-RCAN1	Sigma-Aldrich ABN1676M Anti-Calcipressin-1	SAB6012163 Anti Regulator Of Calcineurin 1 Antibody, clone 24GB1335, Rabbit Monoclonal
description ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody	description serum, from rabbit	description clone 24GB1335, recombinant rabbit monoclonal, expressed in HEK293 cells
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit (Monoclonal)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form serum	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
mol wt antigen ~26 kDa	mol wt 28 kDa	mol wt -	mol wt 28 kDa
UniProt accession no. P53805	UniProt accession no. P53805	UniProt accession no. Q6IN33	UniProt accession no. P53805

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Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

WGK

nwg

Storage Class

12 - Non Combustible Liquids

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