F3055
Flavopiridol hydrochloride hydrate
≥98% (HPLC), CDK and CDC25 phosphatase family inhibitor, powder
Synonym(s):
(−)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride, L-86-8276, NSC-649890
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $171.00 |
25 mg | Available to ship TODAYfromMILWAUKEE | $645.00 |
About This Item
Product Name
Flavopiridol hydrochloride hydrate, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to light brown
solubility
H2O: ~2 mg/mL, DMSO: >5 mg/mL
storage temp.
2-8°C
SMILES string
OC1=C(C(C=C(C2=C(Cl)C=CC=C2)O3)=O)C3=C([C@H]4CCN(C)C[C@H]4O)C(O)=C1.Cl
InChI
1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
InChI key
LGMSNQNWOCSPIK-LWHGMNCYSA-N
Gene Information
human ... CDK1(983), CDK2(1017), CDK4(1019), CDK6(1021), CDK7(1022), CDK9(1025)
Application
- as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
- as an RNA polymerase inhibitor to study its effects on hepatic cells
- as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), powder | description ≥99.0% | description analytical standard | description British Pharmacopoeia (BP) Reference Standard |
| assay ≥98% (HPLC) | assay ≥99.0% | assay ≥99.0% (HPLC) | assay - |
| form powder | form powder | form - | form solid |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
| solubility H2O: ~2 mg/mL, DMSO: >5 mg/mL | solubility - | solubility - | solubility - |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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