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F8512

Anti-Fibrinogen antibody produced in goat

whole antiserum

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2 mL
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$167.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00162408
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), QPA
Citations:
18

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biological source

goat

Quality Segment

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

human

technique(s)

indirect ELISA: 1:10,000, quantitative precipitin assay: 2.0 mg/mL

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

General description

Fibrinogen is a thrombin-coagulable soluble plasma 340 kDa glycoprotein, composed of paired sets of three subunits i.e. α, β, γ. It plays a crucial role in protecting the vascular network against the loss of blood after tissue injury. Among three subunits, β and γ subunits contain one N-glycosylation site, which is occupied by a biantennary N-glycan. It contains three pairs of disulfide-bonded chains called α, β and γ which further folded into four structural domains: the D, E, connector, and the COOH-terminal region of the Aα chain.
The fibrinogen gene cluster consists of fibrinogen α, β and γ chains. It is localized on human chromosome locus 4q31.3−4q32.1.

Immunogen

human fibrinogen

Application

Anti-Fibrinogen antibody is suitable for immunostaining in fibrin deposition analysis of mouse livers and capturing antibodies in the sandwich ELISA. It is also suitable for indirect ELISA at a dilution of 1:10,000 and quantitative precipitin assay at 2.0mg/mL concentration.
Anti-Fibrinogen antibody produced in goat has been used in:
  • western blotting detection in human colon adenocarcinoma cell line
  • detecting fibrinogen in plasma
  • immunoassay of human platelet free plasma (PFP)

Biochem/physiol Actions

The antiserum has been determined to be immunospecific for fibrinogen by immunoelectrophoresis versus human plasma and fibrinogen.
Plasmin attacks the Aα chain COOH domain to produce the heterogeneous fragment X. Multiple round of degradation ended with terminal digestion products−fragments D and E which represent the major globular domains in fibrinogen. Mutations in this gene lead to several disorders, including hypofibrinogenemia and afibrinogenemia.

Preparation Note

treated to remove lipoproteins

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-Fibrinogen antibody produced in goat whole antiserum

Sigma-Aldrich

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Anti-Fibrinogen antibody produced in goat

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Sigma-Aldrich

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Sigma-Aldrich

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Monoclonal Anti-Fibrinogen antibody produced in mouse clone 85D4, ascites fluid

Sigma-Aldrich

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Monoclonal Anti-Fibrinogen antibody produced in mouse

description

whole antiserum

description

clone FG-21, ascites fluid

description

whole antiserum

description

clone 85D4, ascites fluid

antibody form

whole antiserum

antibody form

ascites fluid

antibody form

whole antiserum

antibody form

ascites fluid

biological source

goat

biological source

mouse

biological source

goat

biological source

mouse

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... TF(7018)

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

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