F8512
Anti-Fibrinogen antibody produced in goat
whole antiserum
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 2 mL | Available to ship TODAYfromMILWAUKEE | $167.00 |
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), QPA
Citations:
18
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
indirect ELISA: 1:10,000, quantitative precipitin assay: 2.0 mg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
General description
Fibrinogen is a thrombin-coagulable soluble plasma 340 kDa glycoprotein, composed of paired sets of three subunits i.e. α, β, γ. It plays a crucial role in protecting the vascular network against the loss of blood after tissue injury. Among three subunits, β and γ subunits contain one N-glycosylation site, which is occupied by a biantennary N-glycan. It contains three pairs of disulfide-bonded chains called α, β and γ which further folded into four structural domains: the D, E, connector, and the COOH-terminal region of the Aα chain.
The fibrinogen gene cluster consists of fibrinogen α, β and γ chains. It is localized on human chromosome locus 4q31.3−4q32.1.
Immunogen
human fibrinogen
Application
Anti-Fibrinogen antibody is suitable for immunostaining in fibrin deposition analysis of mouse livers and capturing antibodies in the sandwich ELISA. It is also suitable for indirect ELISA at a dilution of 1:10,000 and quantitative precipitin assay at 2.0mg/mL concentration.
Anti-Fibrinogen antibody produced in goat has been used in:
- western blotting detection in human colon adenocarcinoma cell line
- detecting fibrinogen in plasma
- immunoassay of human platelet free plasma (PFP)
Biochem/physiol Actions
The antiserum has been determined to be immunospecific for fibrinogen by immunoelectrophoresis versus human plasma and fibrinogen.
Plasmin attacks the Aα chain COOH domain to produce the heterogeneous fragment X. Multiple round of degradation ended with terminal digestion products−fragments D and E which represent the major globular domains in fibrinogen. Mutations in this gene lead to several disorders, including hypofibrinogenemia and afibrinogenemia.
Preparation Note
treated to remove lipoproteins
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form whole antiserum | antibody form ascites fluid | antibody form whole antiserum | antibody form whole antiserum |
| biological source goat | biological source mouse | biological source goat | biological source goat |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| Gene Information human ... FGA(2243), FGB(2244), FGG(2266) | Gene Information human ... FGA(2243), FGB(2244), FGG(2266) | Gene Information human ... TF(7018) | Gene Information - |
| technique(s) indirect ELISA: 1:10,000, quantitative precipitin assay: 2.0 mg/mL | technique(s) indirect ELISA: 1:4,000 | technique(s) indirect ELISA: 1:50,000, quantitative precipitin assay: 3.2-4.8 mg/mL | technique(s) indirect ELISA: 1:30,000, quantitative precipitin assay: 4.0 mg/mL |
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Storage Class
12 - Non Combustible Liquids
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Related Content
Datasheet
Ana L Flores-Mireles et al.
The Journal of urology, 196(2), 416-421 (2016-02-02)
Catheter associated urinary tract infections account for approximately 40% of all hospital acquired infections worldwide with more than 1 million cases diagnosed annually. Recent data from a catheter associated urinary tract infection animal model has shown that inflammation induced by
N E Kirschbaum et al.
The Journal of biological chemistry, 265(23), 13669-13676 (1990-08-15)
The COOH-terminal portion of the A alpha chain of human fibrinogen is highly susceptible to proteolytic degradation. This property has prevented isolation of the COOH-terminal domain of fibrinogen for the direct investigation of its functional characteristics. Human fibrinogen was degraded
A quantitative immunoassay for lung cancer biomarker CIZ1b in patient plasma.
Coverley D, et al.
Clinical Biochemistry, 50(6), 336-343 (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F8512-2ML | 04061833620748 |