After performing a NCBI protein BLAST with the antibody immunogen sequence corresponding to amino acids 517-536 of human glucocerebrosidase (GBA) against either GBA2 or GBA3, there is 100% homology with GBA2 and 20% homology with GBA3. Therefore, binding with GBA2 is expected, while binding with GBA3 is not anticipated.
G4171
Anti-Glucocerebrosidase (C-terminal) antibody produced in rabbit
Enhanced Validation
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-D-glucosyl-N-acylsphingosine glucohydrolase, Anti-GBA, Anti-GBA1, Anti-Glucosidase, beta (Gluc), Anti-Glucosylceramidase (GlcCerase), Anti-Lysosomal glucocerebrosidase
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| Size/SKU | Availability | Price |
|---|---|---|
25 μL | Available to ship TODAYfromMILWAUKEE | $196.00 |
200 μL | Available to ship TODAYfromMILWAUKEE | $587.00 |
About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
62
$196.00
Available to ship TODAYDetails
A recombinant, preservative-free antibody is available for your target. Try ZRB1325
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~60 kDa
species reactivity
human, mouse, rat
packaging
antibody small pack of 25 μL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1 mg/mL
technique(s)
western blot: 1-2 μg/mL using HEK293-T cells lysate expressing human glucocerebrosidase (GBA)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GBA(2629)
mouse ... Gba(14466)
General description
Glucocerebrosidase is an enzyme having glucosylceramidase activity. Defect in lysosomal hydrolase glucocerebrosidase results in Gaucher disease. Mutation in GBA will retard or block the transport of GBA to endoplasmic reticulum. Anti-glucocerebrosidase (C-terminal) antibody can be used to incubate the SDS-PAGE gel. Anti-Glucocerebrosidase antibody reacts specifically with human GBA.
Immunogen
synthetic peptide corresponding to amino acids 517-536 of human glucocerebrosidase (GBA), conjugated to KLH. This sequence is identical in rat GBA and highly conserved in mouse GBA (single amino acid substitution).
Application
Anti-Glucocerebrosidase (C-terminal) antibody produced in rabbit has been used in
Anti-glucocerebrosidase (C-terminal) antibody can be used in western blotting and immunoblotting.
Biochem/physiol Actions
Glucocerebrosidase (GBA) activity is reduced in human with mutations in GBA gene and causes accumulation of glucosylceramide (GlcCer). Fibroblasts from patients with defined GBA mutations show either retarded or blocked transport of GBA in the endoplasmic reticulum. Mutations in the human GBA gene may contribute to the development of common age-related dementia known as dementia with Lewy bodies. Several studies indicate that mutations in the human GBA gene are associated with early-onset Parkinson disease.
Glucocerebrosidase is an enzyme having glucosylceramidase activity. Defect in lysosomal hydrolase glucocerebrosidase results in Gaucher disease. Mutation in GBA will retard or block the transport of GBA to endoplasmic reticulum.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution | description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution | description ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution | description affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| mol wt antigen ~60 kDa | mol wt antigen ~60 kDa | mol wt antigen ~58 kDa | mol wt antigen ~58 kDa |
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Storage Class
12 - Non Combustible Liquids
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G4171 Anti-Glucocerebrosidase (C-terminal) antibody produced in rabbit Does this antibody cross react with GBA2 or GBA3?
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