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L5044

Anti-LXRα (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-LX receptor, alpha, Anti-LXR-a, Anti-LXRA, Anti-Liver X receptor a, Anti-NR1H3, nuclear receptor subfamily 1 group H, member 3, Anti-RLD-1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
7
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biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 1-2 μg/mL using HEK-293T cells expressing human LXRα

UniProt accession no.

Q13133

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NR1H3(10062)
mouse ... Nr1h3(22259)
rat ... Nr1h3(58852)

General description

The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.
The liver X receptors (LXRs) are encoded by two different genes, LXRα (NR1H3) and LXRβ (NR1H2). LXRα expression is restricted to macrophages and tissues involved in lipid metabolism.

Application

Anti-LXRα (N-terminal) antibody produced in rabbit has also been used for western blotting.
Anti-LXRα (N-terminal) antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions

Liver X receptors (LXRs) heterodimerize with the retinoid X receptor (RXR) and bind to the LXR response element (LXRE). LXRs regulate cholesterol homeostasis by modulating the transcription of genes involved in its catabolism, storage, absorption and transport. Activated LXRs are also potent inhibitors of inflammatory responses in macrophages and reduce inflammation in vivo. LXR expression and activation with LXRs ligands have also been shown to modulate atherosclerotic lesions. LXRα/β-deficient mice show enhanced lipid-loaded foam cell accumulation. LXRs have been suggested to play an important role in Alzheimer′s disease (AD) pathogenesis.
The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-LXRα (N-terminal) antibody produced in rabbit ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

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Sigma-Aldrich

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antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

biological source

rabbit

biological source

goat

biological source

mouse

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

Gene Information

human ... NR1H3(10062)
mouse ... Nr1h3(22259)
rat ... Nr1h3(58852)

Gene Information

human ... NR1H3; NR1H2(10062)

Gene Information

human ... NR1H2(7376)

Gene Information

human ... LRP8(7804)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

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