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Anti-LRRK2 (C-terminal region) antibody produced in rabbit

Name: Anti-LRRK2 (C-terminal region) antibody produced in rabbit
Brand: SIGMA
Price: 560 USD
Availability: InStock

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

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Enhanced Validation

Synonym(s):

Anti-AURA17, Anti-Dardarin, Anti-Leucine-rich repeat protein kinase 2, Anti-PARK8, Anti-RIPK7, Anti-ROCO2

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$560.00

About This Item

NACRES:

NA.44

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$560.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~240 kDa

species reactivity

rat, mouse, human

enhanced validation

recombinant expression
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concentration

~1.0 mg/mL

technique(s)

western blot: 2-4 μg/mL using HEK-293T cells expressing human LRRK2, and using rat and mouse brain extracts (S2 fraction)

UniProt accession no.

Q5S007

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRRK2(120892)
mouse ... Lrrk2(66725)
rat ... Lrrk2(300160)

Description

General description

Leucine-rich repeat protein kinase 2 (LRRK2) comprises multiple domains, including a leucine-rich repeat (LRR) domain, a Roc (Ras of complex proteins) GTPase domain followed by a C-terminal of ROC (COR) domain, a Ser/Thr kinase domain and a C-terminal Trp-Asp-40 (WD40) domain. The N-terminal region (?900 amino acids) contains ankyrin (ANK) repeats. The LRRK2 homologue LRRK1 shares domain structure similarity with LRRK2.

Application

Anti-LRRK2 (C-terminal region) antibody is suitable for use in western blot (2-4 μg/mL using HEK-293T cells expressing human LRRK2, and using S2 fractions of rat and mouse brain extracts).

Biochem/physiol Actions

Anti-LRRK2 (C-terminal region) antibody is specific for LRRK2 (approx. 240 kDa) in mice, rats and humans.

LRRK2 is a μLtimeric kinase that also functions as a GTPase. LRRK2 activates a calcium/calmodulin-dependent protein kinase kinase (CaMKK)-β/AMPK signaling pathway and subsequently mediates autophagy. Genetic alterations in LRRK2 cause late-onset Parkinson′s disease . Anti-LRRK2 (C-terminal region) antibody is specific for LRRK2 (approx. 240 kDa) in mice, rats and humans. Staining of the LRRK2 band by immunoblotting is specifically inhibited by the LRRK2 immunizing peptide.

LRRK2 mRNA is expressed throughout the brain predominantly within regions of the basal ganglia that are associated with Parkinson′s disease. The presence of multiple protein interaction domains suggests that in addition to its kinase and GTPase activities, LRRK2 may serve as a scaffold protein for the assembly of multiprotein signaling complex. R1441C mutation has been shown to disrupt GTPase activity. G2019S and R1441C, both associated with increased kinase activity.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB5201187	SAB5201192	SAB5201176
Sigma-Aldrich L9918 Anti-LRRK2 (C-terminal region) antibody produced in rabbit	Sigma-Aldrich SAB5201187 Monoclonal Anti-Lrrk2/Dardarin - Biotin antibody produced in mouse	Sigma-Aldrich SAB5201192 Monoclonal Anti-Lrrk2/Dardarin - Rpe antibody produced in mouse	Sigma-Aldrich SAB5201176 Monoclonal Anti-Lrrk2/Dardarin antibody produced in mouse
description ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution	description clone S231B-34, purified immunoglobulin	description clone S231B-34, purified immunoglobulin	description clone S231B-34, purified immunoglobulin
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
conjugate unconjugated	conjugate biotin conjugate	conjugate phycoerythrin (R-PE) conjugate	conjugate unconjugated
biological source rabbit	biological source mouse	biological source mouse	biological source mouse
clone polyclonal	clone S231B-34, monoclonal	clone S231B-34, monoclonal	clone S231B-34, monoclonal
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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