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Anti-Myosin VI antibody, Mouse monoclonal

Name: Anti-Myosin VI antibody, Mouse monoclonal
Brand: SIGMA
Price: 704 USD
Availability: InStock

~1 mg/mL, clone MUD-19, purified from hybridoma cell culture

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Size/SKU	Availability	Price
100 μL	Available to ship TODAYfromMILWAUKEE	$704.00
200 μL	Check Cart for Availability	$727.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02263784

Conjugate:

unconjugated

Clone:

MUD-19, monoclonal

Application:

ARR, ELISA (i), IHC, IP, WB

Citations:

$704.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

MUD-19, monoclonal

form

buffered aqueous solution

mol wt

antigen ~150 kDa by SDS-PAGE

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 2 μg/mL using A431 total cell extract

isotype

IgG1

UniProt accession no.

Q9UM54

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYO6(4646)
mouse ... Myo6(17920)
rat ... Myo6(315840)

Description

General description

Monoclonal Anti-Myosin VI (mouse IgG1 isotype) is derived from the MUD-19 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with a synthetic peptide corresponding to amino acids of human myosin VI. Myosin VI is a relatively abundant widespread unconventional myosin composed of an N-terminal motor domain, a light chain binding neck region, a coil-coiled region and a highly conserved C-terminal domain.

Myosins are actin-dependent motors that have 15 classes based on their phylogenetics . Myosin VI is an unconventional actin motor that moves towards the minus ends of actin filaments, which is opposite to the movement of conventional myosins.

Application

Monoclonal Anti-Myosin VI antibody produced in mouse has been used in:

enzyme-linked immunosorbent assay (ELISA)
immunoprecipitation
western blot assay
immunohistochemistry

Biochem/physiol Actions

Monoclonal Anti-Myosin VI antibody is specific for myosin VI in rats, humans and mice.

Myosin VI is involved in the generation of cell shape change, cell motility, membrane remodeling and possibly in organelle and particle transport or tethering. It is also involved in membrane trafficking pathways in cultured mammalian cells where it is associated with the membrane ruffles and the trans-Golgi network. Myosin VI plays an essential role in the development of the mouse inner ear where it is expressed in the hair cell body, in the actin-rich cuticular plate at the base of the stereocilia and in the peri cuticular necklace region. Myosin VI gene mutations are involved in deafness and balance defects in the Snell′s Waltzer mouse. Myosin VI is present in the Golgi complex and may regulate vesicular transport across the membranes.

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M7443	A1106	SAB4200272
Sigma-Aldrich M0691 Anti-Myosin VI antibody, Mouse monoclonal	Sigma-Aldrich M7443 Anti-MeCP2 antibody, Mouse monoclonal	Sigma-Aldrich A1106 Anti-ATM antibody,Mouse monoclonal	Sigma-Aldrich SAB4200272 Anti-Progerin antibody, Mouse monoclonal
description ~1 mg/mL, clone MUD-19, purified from hybridoma cell culture	description clone Men-8, purified from hybridoma cell culture	description clone MAT3-4G10/8, purified from hybridoma cell culture	description clone 13A4, purified from hybridoma cell culture
species reactivity human, mouse, rat	species reactivity mouse, human, rat, monkey	species reactivity human, mouse	species reactivity human
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture
Gene Information human ... MYO6(4646) mouse ... Myo6(17920) rat ... Myo6(315840)	Gene Information human ... MECP2(4204) mouse ... Mecp2(17257) rat ... Mecp2(29386)	Gene Information human ... ATM(472) mouse ... Atm(11920)	Gene Information human ... LMNA(4000)
biological source mouse	biological source mouse	biological source mouse	biological source mouse
clone MUD-19, monoclonal	clone Men-8, monoclonal	clone MAT3-4G10/8, monoclonal	clone 13A4, monoclonal

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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