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M1946

Anti-monoamine oxydase B (extrémité C-terminale) antibody produced in rabbit

Name: Anti-monoamine oxydase B (extrémité C-terminale) antibody produced in rabbit
Brand: SIGMA
Price: 479 CHF

Validation améliorée

affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution

Synonyme(s) :

Anti-Adrenalin oxidase, Anti-MAO, brain, Anti-MAO, platelet, Anti-Tyramine oxidase

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À vous/Référence	Disponibilité	Prix
200 μL	Vérifier la disponibilité des articles du panier	479.00 CHF

A propos de cet article

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

479.00 CHF

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Propriétés

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~58 kDa

species reactivity

rat, mouse, human

packaging

antibody small pack of 25 μL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 0.25-0.5 μg/mL using rat liver mitochondrial fraction and HEK-293T cells expressing human MAO-B

UniProt accession no.

P27338

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ASCC3(10973), MAOB(4129)
rat ... Maob(25750)

Description

General description

Anti-Monoamine Oxidase B (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human monoamine oxidase B (MAO-B) conjugated to KLH. Monoamine oxidases (MAOs) are mitochondrial flavoprotein enzymes, localized to the mitochondrial outer membrane. MAO-B is mainly found in the brain in dopaminergic, serotonergic and histaminergic neurons, as well as in astrocytes. It is a member of the flavin monoamine oxidase family. MAOB gene is mapped to human chromosome Xp11.

Application

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Anti-Monoamine Oxidase B (C-terminal) specifically recognizes human, mouse and rat MAO-B.

Monoamine oxidases (MAOs) are the main degradative enzymes responsible for the oxidative deamination of biogenic amines, such as epinephrine, norepinephrine, serotonin (5-HT) and dopamine in the central nervous system (CNS) and peripheral tissues. MAO-B is considered the predominant isoform responsible for dopamine metabolism in the human CNS. It participates in the metabolism of neuroactive and vasoactive amines. MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.

Physical form

Supplied as a solution in 0.01 M PBS, pH 7.4, containing 15 mM sodium azide as a preservative.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Cet article	M1821	HPA059299	AV43557
Sigma-Aldrich M1946 Anti-monoamine oxydase B (extrémité C-terminale) antibody produced in rabbit	Sigma-Aldrich M1821 Anti-monoamine oxydase B antibody produced in rabbit	Sigma-Aldrich HPA059299 Anti-MAOA antibody produced in rabbit	Sigma-Aldrich AV43557 Anti-MAOB antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Gene Information human ... ASCC3(10973), MAOB(4129) rat ... Maob(25750)	Gene Information human ... ASCC3(10973), MAOB(4129) rat ... Maob(25750)	Gene Information human ... MAOA(4128)	Gene Information human ... MAOB(4129)
species reactivity rat, mouse, human	species reactivity mouse, rat, human	species reactivity human	species reactivity human, rat, guinea pig, horse, mouse, dog
UniProt accession no. P27338	UniProt accession no. P27338	UniProt accession no. P21397	UniProt accession no. P27338

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Classe de stockage

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c