Key Documents

Anti-Myosin Iβ (Nuclear) antibody produced in rabbit

Name: Anti-Myosin Iβ (Nuclear) antibody produced in rabbit
Brand: SIGMA
Price: 538.9 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Myh 2, Anti-Myo1c, Anti-Myr 2

Select a Size

Change View

Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$634.00 $538.90

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD05665241

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IF, WB

Citations:

$538.90

List Price$634.00Save 15%

Web-Only Promotion

Check Cart for Availability

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~120 kDa

species reactivity

human, mouse, canine, rat

technique(s)

indirect immunofluorescence: 1:50 using mouse NIH3T3 cells, microarray: suitable, western blot: 1:1,000 using extract of human HeLa cells nuclei and dog MDCK cells

UniProt accession no.

O00159

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYO1C(4641)
mouse ... Myo1c(17913)
rat ... Myo1c(65261)

Description

General description

Myosins belong to a superfamily of actin-based motor proteins comprising to date at least 15 classes. Myosin I (also designated myosin-1c, myo1c, M1C, myr 2 and myh 2) is a widely distributed single-headed myosin composed of an N-terminal motor domain, a calmodulin-light chain binding neck region, and a short C-terminal domain. In mammalian cells, myosin I is usually found in the cytoplasm and is especially enriched in perinuclear regions and dynamic cell margins. Myosin Iβ is found in a variety of cells such as kidney tubular cells and inner-ear hair cells.

Immunogen

synthetic peptide corresponding to amino acid residues 1-16 of the heavy chain of mouse myosin Iβ (nuclear form). This sequence is missing from the other myosin I isoforms as well as from other currently known myosins.

Application

Anti-Myosin Iβ (Nuclear) antibody produced in rabbit has been used in:

western blot
confocal immunofluorescence
immunogold labeling
immunofluorescence
co-immunoprecipitation experiments
immunostaining

Biochem/physiol Actions

Myosin I is involved in cell motility, microvilli anchorage, vesicular and organelle transport and signal transduction. Myosin I associate with lipid membranes through its tail domain while its motor domain interacts with actin filaments. Myosin Iβ (nuclear) co-localizes with RNA polymerases I and II and possibly acts as a molecular motor to power transcription.

Recognizes the heavy chain of the nuclear form of human myosin Iβ. Additional bands may be detected in some preparations.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	M4276	HPA005924	HPA013607
Sigma-Aldrich M3567 Anti-Myosin Iβ (Nuclear) antibody produced in rabbit	Sigma-Aldrich M4276 Monoclonal Anti-Myosin (Skeletal, Fast) antibody produced in mouse	Sigma-Aldrich HPA005924 Anti-MYO1C antibody produced in rabbit	Sigma-Aldrich HPA013607 Anti-MYO1B antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description clone MY-32, ascites fluid	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
antibody form affinity isolated antibody	antibody form ascites fluid	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
UniProt accession no. O00159	UniProt accession no. Q5SX40, P12882	UniProt accession no. O00159	UniProt accession no. O43795
species reactivity human, mouse, canine, rat	species reactivity rat, chicken, rabbit, mouse, human, bovine, guinea pig, feline	species reactivity human	species reactivity human

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.