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M7060

Monoclonal Anti-Moesin antibody produced in mouse

clone 38/87, purified immunoglobulin, buffered aqueous solution

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0.2 mL
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$584.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01633643
Conjugate:
unconjugated
Clone:
38/87, monoclonal
Application:
ELISA (i), FACS, ICC, IHC (p), IP, WB
Citations:
4

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biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

38/87, monoclonal

form

buffered aqueous solution

mol wt

antigen 78-80 kDa

species reactivity

human, bovine, rat, mouse, pig

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 0.5-1 μg/mL using whole extract of cultured human acute T cell leukemia Jurkat cells

isotype

IgG1

UniProt accession no.

P26038

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MSN(4478)
mouse ... Msn(17698)
rat ... Msn(81521)

Immunogen

bovine uterus moesin.

Application

Mouse monoclonal clone 38/87 anti-Moesin antibody may be used for ELISA, immunoblotting (a closely spaced doublet of 78/80 kDa) immunoprecipitation, immunohistochemistry (reported for frozen sections and for formalin-fixed paraffin-embedded sections following boiling in 0.01M citrate buffer pH 6), immunocytochemistry (3.7% paraformaldehyde, 0.1% Triton X-100), flow cytometry (3-3.7% paraformaldehyde, 0.1-0.25% Triton X-100) and electron microscopy. The intensity of the fainter doublet‘s upper band seen in immunoblotting varies depending on the tissue. The antibody has been used to inhibit both the binding of proteoheparan sulfate to smooth muscle cells, and the infectivity of measles virus.

Biochem/physiol Actions

Mouse monoclonal clone 38/87 anti-Moesin antibody recognizes the 78 kDa moesin and 80 kDa radixin molecules. It does not react with talin or ezrin. Reactivity has been reported with human, bovine, porcine, rat and mouse moesin.
The ERM (ezrin-radixin-moesin) proteins, members of the talin-protein 4.1- merlin/schwannomin superfamily, are general cross-linkers between the plasma membrane and actin filaments. They provide such links through their N-terminal halves that associate with integral membrane proteins either directly or indirectly through adapter molecules, and through their C-terminal halves that associate with F-actin. ERM proteins are involved not only in cytoskeletal organization but also in signal transduction and apoptosis. Because their expression is regulated in a tissue-specific manner, each ERM protein has been proposed to have unique functions. There is approximately 80% homology between moesin, ezrin and radixin. These proteins are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures. However, moesin (in contrast to radixin and ezrin) is strongly expressed in endothelium of vessels, in T and B lymphocytes, in basal layers of squamous epithelium and glandular ducts, and in cells of carcinoma and mesothelioma. Moesin is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines. It is overexpressed in some estrogen receptor (ER)-negative cell lines but absent from ER-positive ones, suggesting that it may play a role in the invasiveness and pattern of metastasis characteristic of ER-negative breast cancers.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Monoclonal Anti-Moesin antibody produced in mouse clone 38/87, purified immunoglobulin, buffered aqueous solution

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Monoclonal Anti-phospho-Histone H3 (pSer28) antibody produced in rat

description

clone 38/87, purified immunoglobulin, buffered aqueous solution

description

clone Men-8, purified from hybridoma cell culture

description

clone GS-2C4, ascites fluid

description

~0.5 mg/mL, clone HTA28, purified immunoglobulin, buffered aqueous solution

species reactivity

human, bovine, rat, mouse, pig

species reactivity

mouse, human, rat, monkey

species reactivity

bovine, pig, human, rabbit

species reactivity

bovine, mouse, hamster, human

Gene Information

human ... MSN(4478)
mouse ... Msn(17698)
rat ... Msn(81521)

Gene Information

human ... MECP2(4204)
mouse ... Mecp2(17257)
rat ... Mecp2(29386)

Gene Information

human ... GSN(2934)

Gene Information

human ... H3F3A(3020), H3F3B(3021), HIST1H3A(8350), HIST1H3B(8358), HIST1H3C(8352), HIST1H3D(8351), HIST1H3E(8353), HIST1H3F(8968), HIST1H3G(8355), HIST1H3H(8357), HIST1H3I(8354), HIST1H3J(8356), HIST2H3A(333932), HIST2H3C(126961), HIST3H3(8290)
mouse ... H3f3a(15078), H3f3b(15081), Hist1h3a(360198), Hist1h3b(319150), Hist1h3c(319148), Hist1h3d(319149), Hist1h3e(319151), Hist1h3f(260423), Hist1h3g(97908), Hist1h3h(319152), Hist1h3i(319153), Hist2h3b(319154), Hist2h3c1(15077), Hist2h3c2(97114)

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

antibody form

purified immunoglobulin

clone

38/87, monoclonal

clone

Men-8, monoclonal

clone

GS-2C4, monoclonal

clone

HTA28, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rat

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